Journal of the Neurological Sciences
Volume 215, Issue 1 , Pages 51-55, 15 November 2003

Plasma levels of antioxidant vitamins C and E are decreased in vascular parkinsonism

  • George P. Paraskevas

      Affiliations

    • Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas. Sophias Avenue, Athens 11528, Greece
    • ,
  • Elisabeth Kapaki

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +30-210-7289125; fax: +30-210-9811638.
    • Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas. Sophias Avenue, Athens 11528, Greece
    • ,
  • Olga Petropoulou

      Affiliations

    • Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas. Sophias Avenue, Athens 11528, Greece
    • ,
  • Maria Anagnostouli

      Affiliations

    • Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas. Sophias Avenue, Athens 11528, Greece
    • ,
  • Vasileios Vagenas

      Affiliations

    • Neurological Clinic, First Hospital of Social Insurance Institution, Athens, Greece
    • ,
  • Constantine Papageorgiou

      Affiliations

    • Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas. Sophias Avenue, Athens 11528, Greece
    • Deceased.

Received 20 March 2003; accepted 6 June 2003.

Abstract 

Oxidative stress is an important mechanism of cell death in Parkinson's disease (PD) and brain ischemia. Vitamins C, E and A are important antioxidants and deficiency of these agents has been implicated in the mechanisms of atherosclerosis. We measured the levels of the above antioxidant vitamins in 44 patients with PD, 12 patients with vascular parkinsonism (VP), 11 patients with other parkinsonism syndromes of various causes and 39 controls. Vitamin A levels did not differ between groups. Vitamins C and E were found decreased in VP, while they were normal in PD indicating low levels of antioxidant vitamins in VP and stressing the necessity of maintaining sufficient dietary intake of these agents in the elderly.

Keywords:  Parkinson's disease, Vascular parkinsonism, Vitamin C, Ascorbate, Vitamin E, Tocopherol, Vitamin A, Retinol

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0022-510X(03)00184-9

doi:10.1016/S0022-510X(03)00184-9

Journal of the Neurological Sciences
Volume 215, Issue 1 , Pages 51-55, 15 November 2003

Article Tools

* Image Usage & Resolution