« Previous
Next »
Journal of the Neurological Sciences
Volume 215, Issue 1
, Pages 37-44
, 15 November 2003
Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor
References
- . Glatiramer acetate in the treatment of multiple sclerosis. Expert Opin. Pharmacother. 2001;2(7):1149–1165
- Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology. 1995;45(7):1268–1276
- Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Neurology. 2001;57(12 Suppl. 5):S46–S53 [1998, classical article]
- . United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates. Multiple Sclerosis Study Group and the MRI Analysis Center. Mult. Scler. 2001;7(1):33–41
- Treatment of multiple sclerosis with copolymer-1 (Copaxone): implicating mechanisms of Th1 to Th2/Th3 immune-deviation. J. Neuroimmunol. 1998;92(1–2):113–121
- . Mechanisms of action of glatiramer acetate in multiple sclerosis. Neurology. 2001;56(6):702–708
- Mechanisms of immunomodulation by glatiramer acetate. Neurology. 2000;55(11):1704–1714
- . Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients. J. Neuroimmunol. 2000;108(1–2):201–206
- . Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS. Mult. Scler. 2001;7(4):209–219
- Glatiramer acetate (copolymer-1)-specific, human T cell lines: cytokine profile and suppression of T cell lines reactive against myelin basic protein. Neurosci. Lett. 2000;289(3):205–208
- . Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J. Clin. Invest. 2000;105(7):967–976
- . Long-term therapy with glatiramer acetate in multiple sclerosis: effect on T-cells. Mult. Scler. 2001;7(1):43–47
- . Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc. Natl. Acad. Sci. U. S. A. 2000;97(21):11472–11477
- . Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis. Neurology. 2002;58(8 Suppl. 4):S3–S9
- . Glatiramer acetate reduces the proportion of new MS lesions evolving into “black holes”. Neurology. 2001;57(4):731–733
- T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc. Natl. Acad. Sci. U. S. A. 2000;97(13):7446–7451
- Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc. Natl. Acad. Sci. U. S. A. 2001;98(6):3398–3403
- . Dual action of glatiramer acetate (Cop-1) in the treatment of CNS autoimmune and neurodegenerative disorders. Trends Mol. Med. 2002;8(7):319–323
- . Glatiramer acetate-specific T-helper 1 and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain. 2002;125:2381–2391
- . BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?. Brain. 2002;125(Pt 1):75–85
- Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J. Exp. Med. 1999;189(5):865–870
- . IFN-beta gene transfer into the central nervous system using bone marrow cells as a delivery system. J. Interferon Cytokine Res. 2002;22(7):783–791
- . Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 1998;18(14):5354–5365
- . Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. U. S. A. 1998;95(10):5779–5784
- . Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGF-beta1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia. J. Neuroimmunol. 1999;95(1–2):8–18
- . Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature. 1992;360(6406):753–755
- . Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nat. Med. 1997;3(7):765–770
- . BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J. Neurosci. 1997;17(24):9583–9595
- The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 1994;36(2):142–148
- . Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 1995;15(12):7810–7820
- . Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. Neuroreport. 1996;7(13):2221–2225
- . Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer. Hum. Gene Ther. 1999;10(18):2987–2997
PII: S0022-510X(03)00177-1
doi: 10.1016/S0022-510X(03)00177-1
© 2003 Elsevier B.V. All rights reserved.
« Previous
Next »
Journal of the Neurological Sciences
Volume 215, Issue 1
, Pages 37-44
, 15 November 2003
