Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 47-53 , 15 September 2003

Increased hypoxic blood pressure response in patients with amyotrophic lateral sclerosis

  • Martin J Hecht

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +49-9131-8533001; fax: +49-9131-8534846.
    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    • ,
  • Clive M Brown

      Affiliations

    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    • ,
  • Felix Mittelhamm

      Affiliations

    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    • ,
  • Dierk Werner

      Affiliations

    • Department of Cardiology, University of Erlangen-Nuremberg, Erlangen, Germany
    • ,
  • Dieter Heuss

      Affiliations

    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    • ,
  • Bernhard Neundörfer

      Affiliations

    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany
    • ,
  • Max-Josef Hilz

      Affiliations

    • Department of Neurology, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany

Received 19 November 2002 ,Revised 29 April 2003 ,Accepted 30 April 2003.

References 

  1. Toepfer M, Schroeder M, Klauser A, Lochmuller H, Hirschmann M, Riepl RL, et al.  Delayed colonic transit times in amyotrophic lateral sclerosis assessed with radio-opaque markers. Eur. J. Med. Res. 1997;2(11):473–476
  2. Toepfer M, Folwaczny C, Lochmuller H, Schroeder M, Riepl RL, Pongratz D, et al.  Noninvasive (13)C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis. Digestion. 1999;60(6):567–571
  3. Dettmers C, Fatepour D, Faust H, Jerusalem F. Sympathetic skin response abnormalities in amyotrophic lateral sclerosis. Muscle Nerve. 1993;16(9):930–934
  4. Masur H, Schulte-Oversohl U, Papke K, Oberwittler C, Vollmer J. Sympathetic skin response in patients with amyotrophic lateral sclerosis. Funct. Neurol. 1995;10(3):131–135
  5. Miscio G, Pisano F. Sympathetic skin response in amyotrophic lateral sclerosis. Acta Neurol. Scand. 1998;98(4):276–279
  6. Kihara M, Takahashi A, Sugenoya J, Kihara Y, Watanabe H. Sudomotor dysfunction in amyotrophic lateral sclerosis. Funct. Neurol. 1994;9(4):193–197
  7. Santos-Bento M, de Carvalho M, Evangelista T, Sales Luis ML. Sympathetic sudomotor function and amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 2001;2(2):105–108
  8. Chida K, Sakamaki S, Takasu T. Alteration in autonomic function and cardiovascular regulation in amyotrophic lateral sclerosis. J. Neurol. 1989;236(3):127–130
  9. Shimizu T, Hayashi H, Kato S, Hayashi M, Tanabe H, Oda M. Circulatory collapse and sudden death in respirator-dependent amyotrophic lateral sclerosis. J. Neurol. Sci. 1994;124(1):45–55
  10. Pisano F, Miscio G, Mazzuero G, Lanfranchi P, Colombo R, Pinelli P. Decreased heart rate variability in amyotrophic lateral sclerosis. Muscle Nerve. 1995;18(11):1225–1231
  11. Shindo K, Tsunoda S, Shiozawa Z. Increased sympathetic outflow to muscles in patients with amyotrophic lateral sclerosis: a comparison with other neuromuscular patients. J. Neurol. Sci. 1995;134(1–2):57–60
  12. Shimizu T, Kato S, Hayashi M, Hayashi H, Tanabe H. Amyotrophic lateral sclerosis with hypertensive attacks: blood pressure changes in response to drug administration. Clin. Auton. Res. 1996;6(4):241–244
  13. Linden D, Diehl RR, Berlit P. Reduced baroreflex sensitivity and cardiorespiratory transfer in amyotrophic lateral sclerosis. Electroencephalogr. Clin. Neurophysiol. 1998;109(5):387–390
  14. Ichihara N, Deguchi K, Fujii S, Ishibashi T, Hatanaka Y. A case of amyotrophic lateral sclerosis presenting with circulatory collapse during artificial respiration. Rinsho Shinkeigaku. 2000;40(9):906–910
  15. Hilz MJ, Hecht MJ, Mittelhamm F, Neundörfer B, Brown CM. Baroreflex stimulation shows impaired cardiovagal and preserved vasomotor function in early stage amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 2002;3(3):137–144
  16. Oey PL, Vos PE, Wieneke GH, Wokke JH, Blankestijn PJ, Karemaker JM. Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis. Muscle Nerve. 2002;25(3):402–408
  17. Druschky A, Spitzer A, Platsch G, Claus D, Feistel H, Druschky K, et al.  Cardiac sympathetic denervation in early stages of amyotrophic lateral sclerosis demonstrated by 123I-MIBG-SPECT. Acta Neurol. Scand. 1999;99(5):308–314
  18. Gelinas DF, Miller RG. A treatable disease: a guide to the management of amyotrophic lateral sclerosis. In:  Brwon RH,  Meininger V,  Swash M editor. Amyotrophic lateral sclerosis. London: Martin Dunitz; 2000;p. 405–423
  19. Shimizu T, Kawata A, Kato S, Hayashi M, Takamoto K, Hayashi H, et al.  Autonomic failure in ALS with a novel SOD1 gene mutation. Neurology. 2000;54(7):1534–1537
  20. Somers VK, Dyken ME, Mark AL, Abboud FM. Parasympathetic hyperresponsiveness and bradyarrythmias during apnoea in hypertension. Clinic. Auton. Res. 1992;2:171–176
  21. Brooks BR, Miller RG, Swash M, Munsat TL. Diseases. WFoNRGoMN. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Mot. Neuron Disord. 2000;1(5):293–299
  22. Spicuzza L, Gabutti A, Porta C, Montano N, Bernardi L. Yoga and chemoreflex response to hypoxia and hypercapnia. Lancet. 2000;356:1495–1496
  23. Bernardi L, Passino C, Serebrovskaya Z, Serebrovskaya T, Appenzeller O. Respiratory and cardiovascular adaptations to progressive hypoxia. Eur. Heart J. 2001;22(10):879–886
  24. Bernardi L, Gabutti A, Porta C, Spicuzza L. Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity. J. Hypertens. 2001;19(12):2221–2229
  25. Bernardi L, Bianchini B, Spadacini G, Leuzzi S, Valle F, Marchesi E, et al.  Demonstrable cardiac reinnervation after human heart transplantation by carotid baroreflex modulation of RR interval. Circulation. 1995;92:2895–2903
  26. Berger A, Hornbein T. Control of respiration. In:  Patton H,  Fuchs A,  Hille B,  Scher A,  Steiner R editor. Textbook of physiology. Philadelphia: W.B. Saunders; 1989;p. 1026–1045
  27. Somers KV, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor control of sympathetic nerve activity in normal humans. J. Clin. Invest. 1991;87:1953–1957
  28. Pisarri TE, Kendrick JE. Reduced effectiveness of the carotid baroreflex during arterial hypoxia in dogs. Am. J. Physiol. 1984;247(4 Pt 2):H623–H630
  29. Ponikowski P, Chua TP, Piepoli M, Ondusova D, Webb-Peploe K, Harrington D, et al.  Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation. 1997;96(8):2586–2594
  30. Eckberg DL, Sleight P. Human baroreflexes in health and disease. Oxford: Clarendon Press; 1992;
  31. Hedner JA, Wilcox I, Laks L, Grunstein RR, Sullivan CE. A specific and potent pressor effect of hypoxia in patients with sleep apnoea. Am. Rev. Respir. Dis. 1992;146:1240–1245
  32. Xie A, Skatrud JB, Puleo DS, Morgan BJ. Exposure to hypoxia produces long-lasting sympathetic activation in humans. J. Appl. Physiol. 2001;91:1555–1562
  33. Hennersdorf MG, Hillebrand S, Perings C, Strauer BE. Chemoreflexsensitivity in chronic heart failure patients. Eur. J. Heart Fail. 2001;3:679–684
  34. Hennersdorf MG, Niebch V, Perings C, Strauer BE. Chemoreflex sensitivity as a predictor of arrythmia relapse in ICD recipients. Int. J. Cardiol. 2002;86:169–175
  35. Curtis BM, O'Keefe JHJ. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight and flight. Mayo Clin. Proc. 2002;77(1):45–54

PII: S0022-510X(03)00143-6

doi: 10.1016/S0022-510X(03)00143-6

Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 47-53 , 15 September 2003

Article Tools

* Image Usage & Resolution