Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 7-10, 15 September 2003

Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

  • Mirella Mochi

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +39-51-6442156; fax: +39-51-6442214.
    • Department of Neurological Sciences, University of Bologna Medical School, Bologna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy
    • ,
  • Sabina Cevoli

      Affiliations

    • Department of Neurological Sciences, University of Bologna Medical School, Bologna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy
    • ,
  • Pietro Cortelli

      Affiliations

    • Department of Neurology, University of Modena and Reggio Emilia, Modena, Italy
    • ,
  • Giulia Pierangeli

      Affiliations

    • Department of Neurological Sciences, University of Bologna Medical School, Bologna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy
    • ,
  • Chiara Scapoli

      Affiliations

    • Department of Biology, University of Ferrara, Ferrara, Italy
    • ,
  • Stefano Soriani

      Affiliations

    • Institute of Pediatrics, University of Ferrara, Italy
    • ,
  • Pasquale Montagna

      Affiliations

    • Department of Neurological Sciences, University of Bologna Medical School, Bologna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy

Received 10 April 2002; received in revised form 21 February 2003; accepted 7 April 2003.

Abstract 

We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.

Keywords:  Migraine, Genetics, Association study, LDL receptor, chromosome 19

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PII: S0022-510X(03)00124-2

doi:10.1016/S0022-510X(03)00124-2

Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 7-10, 15 September 2003

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