Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 11-14 , 15 September 2003

Induction of conduction block by Campylobacter jejuni lipopolysaccharides and focal neural insult

  • Gal Ifergane

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +972-8-6400660; fax: +972-8-6403660.
    • Neuroimmunology Unit, Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev Faculty of Health Sciences, P.O. Box 151, Beer-Sheva 84101, Israel
  • ,
  • Marina Bersudsky

      Affiliations

    • Neuroimmunology Unit, Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev Faculty of Health Sciences, P.O. Box 151, Beer-Sheva 84101, Israel
  • ,
  • Leonid Kachko

      Affiliations

    • Department of Pathology, Soroka University Medical Center, Ben-Gurion University of the Negev Faculty of Health Sciences, Beer-Sheva, Israel
  • ,
  • Itzhak Wirguin

      Affiliations

    • Neuroimmunology Unit, Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev Faculty of Health Sciences, P.O. Box 151, Beer-Sheva 84101, Israel

Received 6 September 2002 ,Revised 3 March 2003 ,Accepted 8 April 2003.

References 

  1. Hartung HP, Kieseier BC, Kiefer R. Progress in Guillain–Barre syndrome. Curr. Opin. Neurol. 2001;14(5):597–604
  2. Moran AP, Prendergast MM. Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: contribution of gastrointestinal infections to autoimmunity. J. Autoimmun. 2001;16(3):241–256
  3. Thomas FP, Trojaborg W, Nagy C, et al.  Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier. Acta Neuropathol. (Berl.). 1991;82(5):378–383
  4. Yuki N, Yamada M, Koga M, et al.  Animal model of axonal Guillain–Barre syndrome induced by sensitization with GM1 ganglioside. Ann. Neurol. 2001;49(6):712–720
  5. Brown RF, Jackson GD, Martin T, Westbrook RF, Pollard JD, Westland KW. Bacterial lipopolysaccharide induces a conduction block in the sciatic nerves of rats. Lab. Anim. Sci. 1999;49(1):62–69
  6. Wirguin I, Briani C, Suturkova-Milosevic L, et al.  Induction of anti-GM1 ganglioside antibodies by Campylobacter jejuni lipopolysaccharides. J. Neuroimmunol. 1997;78(1–2):138–142
  7. Westphal OJK. Bacterial lipopolysaccharides, extraction with phenol–water and further applications of the procedure. Methods Carbohydr. Chem. 1965;5:83–91
  8. Jacobs DM, Gutowski JA. Solid-phase radioimmunoassay for bacterial lipopolysaccharide. Methods Enzymol. 1982;84:264–272
  9. Ho TW, Li CY, Cornblath DR, et al.  Patterns of recovery in the Guillain–Barre syndromes. Neurology. 1997;48(3):695–700
  10. Kuwabara S, Mori M, Ogawara K, et al.  Axonal involvement at the common entrapment sites in Guillain–Barre syndrome with IgG anti-GM1 antibody. Muscle Nerve. 1999;22(7):840–845
  11. Susuki K, Johkura K, Yuki N, Hasegawa O, Kuroiwa Y. Rapid resolution of nerve conduction blocks after plasmapheresis in Guillain–Barre syndrome associated with anti-GM1b IgG antibody. J. Neurol. 2001;248(2):148–150
  12. Buchwald B, Ahangari R, Weishaupt A, Toyka KV. Intravenous immunoglobulins neutralize blocking antibodies in Guillain–Barre syndrome. Ann. Neurol. 2002;51(6):673–680
  13. Buchwald B, Bufler J, Carpo M, et al.  Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome. Neurology. 2001;56(1):67–74
  14. Takigawa T, Yasuda H, Kikkawa R, Shigeta Y, Saida T, Kitasato H. Antibodies against GM1 ganglioside affect K+ and Na+ currents in isolated rat myelinated nerve fibers. Ann. Neurol. 1995;37(4):436–442
  15. Hirota N, Kaji R, Bostock H, et al.  The physiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons. Brain. 1997;120(Pt 12):2159–2169
  16. Press R, Ozenci V, Kouwenhoven M, Link H. Non-T(H)1 cytokines are augmented systematically early in Guillain–Barre syndrome. Neurology. 2002;58(3):476–478
  17. Zhu J, Mix E, Link H. Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain–Barre syndrome. J. Neuroimmunol. 1998;84(1):40–52
  18. Hund E. Neurological complications of sepsis: critical illness polyneuropathy and myopathy. J. Neurol. 2001;248(11):929–934

PII: S0022-510X(03)00123-0

doi: 10.1016/S0022-510X(03)00123-0

Journal of the Neurological Sciences
Volume 213, Issue 1 , Pages 11-14 , 15 September 2003