Journal of the Neurological Sciences
Volume 208, Issue 1 , Pages 51-56 , 15 April 2003

Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylase

  • Hiroshi Mitoma

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-3-5391-9355; fax: +81-3-5391-9355.
    • Mitoma Neurological Clinic, 1-2-10 Minami-Ikebukuro, Toshima, Tokyo, Japan
    • ,
  • Kazuyuki Ishida

      Affiliations

    • Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan
    • ,
  • Masami Shizuka-Ikeda

      Affiliations

    • Department of Neurology, Gunma University, Gunma, Japan
    • ,
  • Hidehiro Mizusawa

      Affiliations

    • Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan

Received 25 April 2002 ,Accepted 28 October 2002.

References 

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  2. Ellis TM, Atkinson MA. The clinical significance of an autoimmune response against glutamic acid decarboxylase. Nat. Med. 1996;2:148–153
  3. Grimaldi LME, Martino G, Braghi S, Quattrini A, Furlan R, Bosi E, et al.  Heterogeneity of autoantibodies in stiff-man syndrome. Ann. Neurol. 1993;34:57–64
  4. Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, et al.  Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD-65 distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J. Exp. Med. 1994;180:595–606
  5. Daw K, Ujihara N, Atkinson M, Powers AC. Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J. Immunol. 1996;156:818–825
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  10. Abele M, Weller M, Mescheriakov S, Bürk K, Dichgans J, Klockgether T. Cerebellar ataxia with glutamic acid decarboxylase autoantibodies. Neurology. 1999;52:857–859
  11. Ishida K, Mitoma H, Song S-Y, Uchihara T, Inaba A, Eguchi S, et al.  Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase. Ann. Neurol. 1999;46:263–267
  12. Mitoma H, Song S-Y, Ishida K, Ymakuni T, Kobayashi T, Mizusawa H. Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J. Neurol. Sci. 2000;175:40–44
  13. Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S-Y, Harigaya Y, Igeta Y, et al.  Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J. Neurol. Neurosurg. Psychiatry. 2001;70:386–389
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PII: S0022-510X(02)00423-9

doi: 10.1016/S0022-510X(02)00423-9

Journal of the Neurological Sciences
Volume 208, Issue 1 , Pages 51-56 , 15 April 2003

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