Journal of the Neurological Sciences
Volume 208, Issue 1 , Pages 105-108, 15 April 2003

Statin therapy and small fibre neuropathy: a serial electrophysiological study

  • Y.L. Lo

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +65-63265003; fax: +65-62203321.
    • Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    • ,
  • T.H. Leoh

      Affiliations

    • Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    • ,
  • L.M. Loh

      Affiliations

    • Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    • ,
  • C.E. Tan

      Affiliations

    • Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore

Received 8 April 2002; received in revised form 8 October 2002; accepted 15 October 2002.

Abstract 

We describe three patients who developed small fibre neuropathy after 1 month of statin therapy with clinical resolution upon prompt drug withdrawal. All patients showed abnormal sympathetic skin responses (SSR) in comparison with controls. SSRs returned to normal in tandem with clinical improvement. One patient redeveloped small and large fibre neuropathy when the similar drug was readministered. The SSR is of value in the electrophysiological assessment and follow-up of statin-related small fibre neuropathy.

Keywords:  Statins, Small fibre neuropathy, Sympathetic skin response

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PII: S0022-510X(02)00396-9

doi:10.1016/S0022-510X(02)00396-9

Journal of the Neurological Sciences
Volume 208, Issue 1 , Pages 105-108, 15 April 2003

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