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Journal of the Neurological Sciences
Volume 206, Issue 2
, Pages 203-208
, 15 February 2003
Mitoxantrone in progressive multiple sclerosis: when and how to treat?
References
- . Evaluation of mitoxantrone for the treatment of multiple sclerosis. Expert Opin. Investig. Drugs. 2000;9:1139–1149
- . Efficacy and toxicity of Cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. Ann. Neurol. 1990;27:591–605
- Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis. Ann. Neurol. 1995;37:30–40
- A placebo-controlled, randomized, double-masked, variable dosage, clinical trial of azathioprine with and without methylprednisolone in multiple sclerosis. Neurology. 1989;39:1018–1026
-
Effect of total lymphoid irradiation in chronic progressive multiple sclerosis.
Lancet. 1986;8495:1405–1408
- . Cyclophosphamide in chronic progressive multiple sclerosis. Maintenance vs. nonmaintenance therapy. Arch. Neurol. 1987;44:823–827
- . Clinical pharmacology of mitoxantrone. Cancer Treat. Rep. 1986;70:1373–1378
-
.
Mitoxantrone inhibits helper function and enhances suppressor activity.
Agents Actions. 1985;16:607–608
- . Morphologic effects of mitoxantrone and a related anthracenedione on lymphoid tissues. Int. J. Immunopharmacol. 1986;8:999–1007
- . Selective immunomodulation by the antineoplastic agent mitoxantrone: I. Suppression of B lymphocyte function. J. Immunol. 1986;137:727–732
- . Immunopharmacologic modulation of experimental allergic encephalomyelitis: low-dose cyclosporin-A treatment causes disease relapse and increased systemic T and B cell mediated myelin-directed autoimmunity. Scand. J. Immunol. 1993;38:499–507
- . Suppression of demyelination by mitoxantrone. Int. J. Immunopharmacol. 1991;13:923–930
- . Selective immunomodulation by the antineoplastic agent mitoxantrone: II. Nonspecific adherent suppressor cells derived from mitoxantrone-treated mice. J. Immunol. 1986;136:2747–2754
- . Suppression of experimental allergic encephalomyelitis by mitoxantrone. Clin. Immunol. Immunopathol. 1985;35:35–42
- . Regional suppression, therapy after onset and prevention of relapses in experimental allergic encephalomyelitis by mitoxantrone. J. Neuroimmunol. 1986;13:175–181
- . Suppression of acute and relapsing experimental allergic encephalomyelitis with mitoxantrone. Clin. Immunol. Immunopathol. 1987;45:122–128
-
.
Prevention of subacute experimental allergic encephalomyelitis in guinea-pigs with desferriowamine, isoprinosine and mitoxantrone.
In:
Gonsette RE, Delmotte P editor. Recent advances in multiple sclerosis therapy. Amsterdam: Elsevier; 1989;p. 299–300
-
.
Mitoxantrone: a new immunosuppressive agent in multiple sclerosis.
In:
Gonsette RE, Delmotte P editor. Recent advances in multiple sclerosis therapy. Amsterdam: Elsevier; 1989;p. 161–164
- . Immunosuppression with mitoxantrone in multiple sclerosis: a pilot study for 2 years in 22 patients. Neurology. 1990;40(Suppl. 1):261; [537P]
- . Die immunsuppressive Therapie der multiplen Sklerose mit Mitoxantron. Fortschr. Neurol. Psychiatr. 1993;61:410–417
- Mitoxantrone (Mx) in the treatment of rapidly progressive MS: a pilot study with serial gadolinium (Gd)-enhanced MRI. Neurology. 1990;40(Suppl. 1):261; [539P]
-
A phase II evaluation of mitoxantrone HCl in the treatment of progressive multiple sclerosis.
Neurology. 1991;41(Suppl. 1):146;
[122P]
- . Serial gadolinium-enhanced magnetic resonance imaging in patients with multiple sclerosis treated with mitoxantrone. Neuroradiology. 1995;37:113–139
- Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. J. Neurol. Neurosurg. Psychiatry. 1997;62:112–118
- Randomized placebo-controlled trial of mitoxantrone in relapsing–remitting multiple sclerosis: 24-month clinical and MRI outcome. J. Neurol. 1997;244:153–159
-
.
Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, randomized observer-blind phase III trial: clinical results and three-year follow-up.
Neurology. 1999;52(Suppl. 2):A290;
[S45.005]
-
.
Mitoxantrone in progressive multiple sclerosis (MS): clinical results and three-year follow-up of the MIMS-trial.
Ectrims 99
Mult. Scler. 1999;5(Suppl. 1):S15;
[56]
-
Hartung H.P., Gonsette R.E., Konig N., Kwiecinski A., Guseo A., Morrissey S., et al. and the MIMS Study Group, A phase III placebo-controlled, double-blind randomised, multicenter trial of mitoxantrone in progressive multiple sclerosis. Lancet (in press).
- . Mitoxantrone immunotherapy in multiple sclerosis. Mult. Scler. 1996;1:329–332
-
The natural history of multiple sclerosis: a geographically based study: I. Clinical course and disability.
Brain. 1989;112:133–146
- An open-trial evaluation of mitoxantrone in the treatment of progressive MS. Neurology. 1993;43:1401–1406
- . Cyclophosphamide in chronic progressive multiple sclerosis: a comparative study. Ital. J. Neurol. Sci. 1998;19:32–36
- . Possible mitoxantrone-induced amenorrhea. Cancer Treat. Rep. 1986;70:659–661
- Acute promyelocytic leukemia following mitoxantrone as a single agent for the treatment of multiple sclerosis. Leukemia. 1998;12:441–442
- . Secondary leukemias induced by topoisomerase-targeted drugs. Biochim. Biophys. Acta. 1998;1400:233–255
-
.
A study of therapy-related acute leukemia after mitoxantrone therapy for multiple sclerosis.
Mult. Sclerosis. 2002;8:441–445
-
Safety profile of mitoxantrone in a cohort of 802 multiple sclerosis patients.
Neurology. 2002;58:A168
- . Multiple sclerosis as a cause of atrial fibrillation and electrocardiographic changes. Arch. Neurol. 1992;49:422–424
- . Evaluation of myocardial muscle functional parameters in patients with multiple sclerosis. Acta Neurol. Scand. 1997;95:335–337
- . Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat. Muscle Nerve. 1998;21:940–942
- . Decrease in heart ventricular ejection fraction during multiple sclerosis. Eur. J. Neurol. 2002;9:287–291
-
Cardiac metabolism and function in patients with multiple sclerosis: a combined 31P-MR-spectroscopy and MRI study.
RoFo. Fortschr. Geb. Rontgenstrahlen Neuen Bildgeb. Verfahr. 2001;173:399–404
- . Use of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. The provincial systemic treatment disease site group. Cancer Prev. Control. 1999;3:145–159
- . Dexrazoxane (ICRF-187). Gen. Pharmacol. 1999;32:155–158
-
.
Novantrone plus dexrazoxane therapy in multiple sclerosis patients: a safety and tolerability pilot study.
Mult. Scler. 2001;7(Suppl. 1):S14;
[0–27]
- . Doxorubicin reduces the iron (III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals. Arch. Biochem. Biophys. 1995;316:680–688
- . Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model. Cancer Res. 1992;52:194–201
- . Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells. Cancer Res. 1993;53:550–556
- The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity. Cancer Chemother. Pharmacol. 2001;48:297–304
- . In vitro effects of dexrazoxane (Zinecard) and classical acute leukemia therapy: time to consider expanded clinical trials?. Leukemia. 2001;15:1517–1520
-
.
Combination therapy with the iron chelator dexrazoxane augments therapeutic efficacy of mitoxantrone in experimental autoimmune encephalomyelitis in lewis rats.
Rev. Neurol. 2000;156(Suppl. 3):3S127;
[P175]
-
.
Cardiotoxicity of chemotherapeutic agents. Incidence, treatment and prevention.
Drug Safety. 2000;22:263–302
- . Anthracycline-induced cardiomyopathy. Semin. Oncol. 2001;28(Suppl. 12):2–7
- Disease modifying therapies in multiple sclerosis. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology. 2002;58:169–178
- 6,9-Bis[(aminoalkyl)amino]benzo[g] isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: synthesis and antitumor evaluations. J. Med. Chem. 1994;37:828–837
-
.
Efficacy of a novel non-cardiotoxic aza-anthracenedione (BBR27781) in acute EAE.
Mult. Scler. 2001;7(Suppl. 1):S20;
[P-010]
PII: S0022-510X(02)00335-0
© 2002 Elsevier Science B.V. All rights reserved.
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Journal of the Neurological Sciences
Volume 206, Issue 2
, Pages 203-208
, 15 February 2003
