Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 23-26 , 15 January 2003

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease

  • J Casademont

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel./fax: +34-93-22-79365.
    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain
    • ,
  • O Miró

      Affiliations

    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain
    • ,
  • B Rodriguez-Santiago

      Affiliations

    • Medical and Molecular Genetics Center, IRO, Barcelona, Spain
    • ,
  • P Viedma

      Affiliations

    • Memory-Alzheimer Unit, ICMSN, Hospital Clı́nic, IDIBAPS, University of Barcelona, Barcelona, Spain
    • ,
  • R Blesa

      Affiliations

    • Memory-Alzheimer Unit, ICMSN, Hospital Clı́nic, IDIBAPS, University of Barcelona, Barcelona, Spain
    • ,
  • F Cardellach

      Affiliations

    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain

Received 14 March 2002 ,Revised 5 August 2002 ,Accepted 6 August 2002.

References 

  1. Bonilla E, Tanji K, Hirano M, Vu TH, DiMauro S, Schon EA. Mitochondrial involvement in Alzheimer's disease. Biochim. Biophys. Acta. 1999;1410:171–182
  2. Manfredi G, Beal MF. The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathol. 2000;10:462–472
  3. Parker WD, Mahr NJ, Filley CM, et al.  Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology. 1994;44:1086–1090
  4. Peterson C, Goldman JE. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. 1986;83:2758–2762
  5. Blass JP. Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer disease?. J. Neurosci. Res. 2001;66:851–856
  6. Cardellach F, Marti MJ, Fernandez-Sola J, et al.  Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease. Neurology. 1993;43:2258–2262
  7. Grau JM, Casademont J, Cardellach F, Fernandez-Sola J. Aging and muscle mitochondrial abnormalities. Ann. Neurol. 1995;38:273–274
  8. Barrientos A, Casademont J, Rotig A, et al.  Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. Biochem. Biophys. Res. Commun. 1996;229:536–539
  9. Weinstock M. Selectivity of cholinesterase inhibition: clinical implications for the treatment of Alzheimer's disease. CNS Drugs. 1999;12:307–323
  10. Birks J, Evans JG, Iakovidou V, Tsolaki M. Rivastigmine for Alzheimer's disease[Cochrane review]. In: The cochrane library. vol. 1:Oxford: Update Software; 2001;
  11. Rustin P, Chretien D, Bourgeron T, Gerard B, Rotig A, Saudubray JM, et al.  Biochemical and molecular investigations in respiratory chain deficiencies. Clin. Chim. Acta. 1994;228:35–51
  12. Miró O, Alonso JR, Jarreta D, Casademont J, Urbano-Márquez A, Cardellach F. Smoking disturbs mitochondrial respiratory chain function and enhances lipid peroxidation on human circulating lymphocytes. Carcinogenesis. 1999;20:1331–1336
  13. Molina JA, de Bustos F, Jimenez-Jimenez FJ, et al.  Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease. Neurology. 1997;48:636–638
  14. Kondrashova MN, Doliba NM. Polarographic observation of substrate-level phosphorylation and its stimulation by acetylcholine. FEBS Lett. 1989;243:153–155
  15. Sato KZ, Fujii T, Watanabe Y, et al.  Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci. Lett. 1999;266:17–20

PII: S0022-510X(02)00319-2

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 23-26 , 15 January 2003

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