Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 23-26, 15 January 2003

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease

  • J Casademont

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel./fax: +34-93-22-79365.
    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain
    • ,
  • O Miró

      Affiliations

    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain
    • ,
  • B Rodriguez-Santiago

      Affiliations

    • Medical and Molecular Genetics Center, IRO, Barcelona, Spain
    • ,
  • P Viedma

      Affiliations

    • Memory-Alzheimer Unit, ICMSN, Hospital Clı́nic, IDIBAPS, University of Barcelona, Barcelona, Spain
    • ,
  • R Blesa

      Affiliations

    • Memory-Alzheimer Unit, ICMSN, Hospital Clı́nic, IDIBAPS, University of Barcelona, Barcelona, Spain
    • ,
  • F Cardellach

      Affiliations

    • Muscle Research Group, Internal Medicine Department, Hospital Clı́nic, IDIBAPS, Faculty of Medicine, University of Barcelona, Villarroel 170:08036, Barcelona, Catalonia, Spain

Received 14 March 2002; received in revised form 5 August 2002; accepted 6 August 2002.

Abstract 

Electron transport chain (ETC) dysfunction has been claimed to contribute to the expression of neurodegenerative disorders. We have investigated the effects of the treatment with rivastigmine, a commonly used cholinesterase inhibitor, on lymphocyte mitochondria of patients with Alzheimer's disease (AD). Increased enzymatic activities of diverse complexes and oxidative capacity of the ETC were found. Enhanced mitochondrial ETC function may contribute to the beneficial effects of rivastigmine on clinical manifestations of AD.

Keywords:  Mitochondria, Electron transport chain, Respiratory chain, Rivastigmine, Neurodegenerative disorders, Dementia

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PII: S0022-510X(02)00319-2

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 23-26, 15 January 2003

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