Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 43-48 , 15 January 2003

Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis

  • Sarah Shapiro

      Affiliations

    • Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
    • ,
  • Ariel Miller

      Affiliations

    • Neuroimmunology Research Unit, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
    • Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
    • Rappaport Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel
    • Equally contributing authors.
    • ,
  • Nitza Lahat

      Affiliations

    • Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
    • Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
    • Rappaport Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel
    • ,
  • Esther Sobel

      Affiliations

    • Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
    • ,
  • Aaron Lerner

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Lady Davis Carmel Medical Center, 7 Michal St., Haifa, 34362, Israel. Tel.: +972-4-8250258; fax: +972-4-8250885.
    • Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
    • Department of Pediatrics, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
    • Equally contributing authors.

Received 25 March 2002 ,Revised 29 July 2002 ,Accepted 14 August 2002.

References 

  1. Sprenger H, Rosler A, Tonn P, Braune HJ, Huffmann G, Gemsa D. Chemokines in the cerebrospinal fluid of patients with meningitis. Clin. Immunol. Immunopathol. 1996;80:155–161
  2. Jander S, Heidenreich F, Stoll G. Serum and CSF levels of soluble intercellular adhesion molecule-1 (ICAM-1) in inflammatory neurologic diseases. Neurology. 1993;43:1809–1813
  3. Yong VW, Krekoski CA, Forsyth PA, Bell R. Edwards DR. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 1998;21:75–80.
  4. Leppert D, Leib SL, Grygar C, Miller KM, Schaad UB, Hollander GA. Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood–brain barrier damage and neurological sequlae. Clin. Infect. Dis. 2000;31:80–84
  5. Goetzl EJ, Banda MJ, Leppert D. Matrix metalloproteinases in immunity. J. Immunol. 1996;156:1–4
  6. Romanic AM, Madri JA. Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol. 1994;4:145–156
  7. Miller A, Shapiro S, Lahat N, Galboiz Y. Matrix metalloproteinases and their inhibitors in brain injury and repair. In:  Abramsky O,  Comspton DAS,  Miller A,  Said G editor. Brain disease: therapeutic strategies and repair. UK: Martin Dunitz; 2002;p. 63–68
  8. Mun-Bryce S, Rosenberg GA. Gelatinase B modulates selective opening of the blood–brain barrier during inflammation. Am. J. Physiol. 1998;274:R1203–R1211
  9. Gijbels K, Galardy RE, Steinman L. Reversal of experimental autoimmune encephalomyelitis with hydroxymate inhibitor of matrix metalloproteinases. J. Clin. Invest. 1994;94:2177–2182
  10. Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase 9 proteolytically activates TGF-β and promotes tumor invasion. Genes Dev. 1999;13:35–48
  11. Gearing AJH, Beckett M, Christodoulou M, Churchill M, Clements J, Davidson AH, et al.  Processing of tumor necrosis factor-α precursor by metalloproteinases. Nature. 1994;370:555–557
  12. Xie B, Laouar A, Huberman E. Autocrine regulation of macrophage differentiation and 92-kDa production by tumor necrosis factor-α via α5B1 integrin in HL-60 cells. J. Biol. Chem. 1998;19:11583–11588
  13. Brooks PC, Stromblad S, Sanders LC, Von Schalscha TL, Aimes RT, Stetler-Stevenson WG, et al.  Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αVβ3. Cell. 1996;85:683–693
  14. Seki T, Joh K, Oh-ishi T. Augmented production of IL-8 in cerebrospinal fluid in bacterial meningitis. Immunology. 1993;80:333–335
  15. Dumont RA, Car BD, Voitenok NN, Junker U, Moser B, Zak O, et al.  Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. Infect. Immun. 2000;68:5756–5763
  16. Spanaus K-S, Nadal D, Pfister H-W, Seebach J, Widmer U, Frei K, et al.  C–X–C and C–C chemokines are expressed in the cerecrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro. J. Immunol. 1997;158:1956–1964
  17. Sprenger H, Rosler A, Tonn P, Braune HJ, Huffman G, Gemsa D. Chemokines in the cerebrospinal fluid of patients with meningitis. Clin. Immunol. Immunopathol. 1996;80:155–161
  18. Rollins BJ. Chemokines. Blood. 1997;90:909–928
  19. Lahrtz F, Piali L, Spanaus K-S, Seebach J, Fontana A. Chemokines and chemotaxis of leukocytes in infectious meningitis. J. Neuroimmunol. 1998;85:33–43
  20. Weber JR, Angstwurm K, Burger W, Einhaupl KM, Dirnagl U. Anti ICAM-1 (CD54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis. J. Neuroimmunol. 1995;63:63–86
  21. Dulkerian SJ, Kilpatrick L, Costarino AT, Mccawley L, Fein J, Corcoan L, et al.  Cytokine elevations in infants with bacterial and aseptic meningitis. J. Pediatr. 1995;126:872–876
  22. Lewczuk P, Reiber H, Tumani H. Intercellular adhesion molecule-1 in cerebrospinal fluid—the evaluation of blood derived and brain derived fractions in neurological diseases. J. Neuroimmunol. 1998;87:156–161
  23. Pleines UE, Stover JF, Kossman T, Trentz O, Morganti-Kossmann MC. Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury. J. Neurotrauma. 1998;15:399–409
  24. Pleines UE, Stover JF, Kossman T, Trentz O, Morganti-Kossman MC. The relationship between clinical efficacy of the specific immunotherapy and serum intercellular adhesion molecule-1 levels. J. Investig. Allergol. Clin. Immunol. 1998;8:123–124
  25. Lee SJ, Benveniste EN. Adhesion molecule expression and regulation on cells of the central nervous system. J. Neuroimmunol. 1999;98:77–88
  26. Kolb SA, Lahrtz F, Paul R, Leppert D, Nadal D, Pfister HW, et al.  Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid. J. Neuroimmunol. 1998;84:143–150
  27. Kieseier BC, Paul R, Koedel U, Seifert T, Clements JM, Gearing AJH, et al.  Differential expression of matrix metalloproteinases in bacterial meningitis. Brain. 1999;122:1579–1587
  28. Pfister HW, Scheld WM. Brain injury in bacterial meningitis: therapeutic implications. Curr. Opin. Cell Biol. 1997;10:254–259
  29. Paul R, Lorenzi S, Koedel U, et al.  Matrix metalloproteinases contribute to blood brain barrier disruption during bacterial meningitis. Ann. Neurol. 1998;44:592–600
  30. Keiseier BC, Seifert T, Giovannoni G, Hartung HP. Matrix metalloproteinases in inflammatory demyelination: targets for treatment. Neurology. 1999;53:20–25
  31. Pagenstecher A, Stalder AK, Kincaid CL, Shapiro SD, Campbell LL. Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. Am. J. Pathol. 1998;152:729–741
  32. Borden P, Heller RA. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Crit. Rev. Eukaryot. Gene Expr. 1997;7:159–178
  33. Newman TA, Woolley ST, Hughes PM, Sibson NR, Anthony DC, Perry VH. T-cell and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases. Brain. 2001;124:2203–2214
  34. Lyons PD, Benveniste EN. Cleavage of membrane-associated ICAM-1 from astrocytes: involvement of metalloproteinase. Glia. 1998;22:103–112
  35. McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science. 2000;289:1202–1206
  36. Opdenakker G, Van-den-Steen PE, Dubois B, Nelissen I, Van-Coillie E, Masure S, et al.  Gelatinase B functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 2001;69:851–859
  37. Waage A, Halstensen A, Espevik T, Brandtzaeg P. Compartmentalization of TNF and IL-1 in meningitis and septic shock. Mediators Inflamm. 1993;2:23–25

PII: S0022-510X(02)00317-9

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 43-48 , 15 January 2003

Article Tools

* Image Usage & Resolution