Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis

Shapiro, Sarah; Miller, Ariel; Lahat, Nitza; Sobel, Esther; Lerner, Aaron

« Previous Next »Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 43-48, 15 January 2003

Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis

Sarah Shapiro
- Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
Ariel Miller
- Neuroimmunology Research Unit, Department of Neurology, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
- Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
- Rappaport Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel
- Equally contributing authors.
Nitza Lahat
- Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
- Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
- Rappaport Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel
Esther Sobel
- Immunology Research Unit, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
Aaron Lerner
- Corresponding author. Department of Pediatrics, Lady Davis Carmel Medical Center, 7 Michal St., Haifa, 34362, Israel. Tel.: +972-4-8250258; fax: +972-4-8250885.
- Bruce Rappaport School of Medicine, Israel Institute of Technology, Haifa, Israel
- Department of Pediatrics, Lady Davis Carmel Medical Center, Haifa, 34362, Israel
- Equally contributing authors.

Received 25 March 2002; received in revised form 29 July 2002; accepted 14 August 2002.

Abstract

The combined expression of the inflammatory mediators, matrix metalloproteinases (MMPs), soluble form of intracellular adhesion molecule ICAM-1 (sICAM-1) and interleukin (IL)-8, was evaluated in children infected with bacterial or viral meningitis. MMP-2 and IL-8 were detected in all CSF samples and were enhanced in both bacterial and viral infected samples, compared to those from control children. The expression of MMP-9 as well as sICAM-1 was not detected in control CSF while observed in viral infected and further elevated in bacterial infected samples. This pilot study supports a role for MMPs, IL-8 and sICAM in infectious meningitis and suggests further research to determine their possible use as biomarkers for various forms of meningeal infection as well as the use of their specific antagonists as potential therapeutic agents for central nervous system (CNS) inflammatory processes.

Keywords: Matrix metalloproteinases, IL-8, ICAM-1 meningitis, CSF