Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 27-30, 15 January 2003

A diffusion tensor MRI study of basal ganglia from patients with ADEM

Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy

Received 5 April 2002; received in revised form 6 August 2002; accepted 6 August 2002.

Abstract 

Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity (D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ (p=0.02) and lower D̄ histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.

Keywords:  Magnetic resonance imaging, Diffusion tensor MRI, Acute disseminated encephalomyelitis, Multiple sclerosis, Basal ganglia

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PII: S0022-510X(02)00310-6

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 27-30, 15 January 2003

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