Journal of the Neurological Sciences
Volume 203 , Pages 177-181 , 15 November 2002

Apolipoprotein E ε4 allele frequency in demented and cognitively impaired patients with and without cerebrovascular disease

  • Latchezar Traykov

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Neurology, University Hospital Alexandrovska, Medical University, 1, St. Georgi Sofiiski str, 1431 Sofia, Bulgaria. Tel./fax: +359-2-952-67-87.
    • INSERM Unit 324, Paris, France
    • Department of Neurology, University Hospital Alexandrovska, Medical University, 1, St. Georgi Sofiiski str, 1431 Sofia, Bulgaria
    • ,
  • Anne-Sophie Rigaud

      Affiliations

    • Hôpital Broca, Paris, France
    • ,
  • Sophie Baudic

      Affiliations

    • INSERM Unit 421, Paris, France
    • ,
  • Alain Smagghe

      Affiliations

    • Hôpital Notre Dame de Bon Secours, Paris, France
    • ,
  • François Boller

      Affiliations

    • INSERM Unit 324, Paris, France
    • ,
  • Françoise Forette

      Affiliations

    • Hôpital Broca, Paris, France

References 

  1. Roses A, Strittmatter W, Saunders A, Schmechel D, Pericak-Vance M. Apolipoprotein E and Alzheimer's disease: state of the field after two years. In:  Roses A,  Weisgraber K,  Christen Y editor. Apolipoprotein E and Alzheimer's disease. Berlin: Springer; 1996;p. 1–10
  2. Noguchi S, Murakami K, Yamada N. Apolipoprotein-E genotype and Alzheimer's disease. Lancet. 1993;342:737
  3. Treves TA, Bornstein NM, Chapman J, Klimovitzki S, Verchovsky R, Asherov A, et al.  APOE-ε4 in patients with Alzheimer disease and vascular dementia. Alzheimer Dis. Assoc. Disord. 1996;10:189–191
  4. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1–12
  5. Eichner JE, Kuller LH, Orchard TJ, Grandits GA, McCallum LM, Ferrell RE, et al.  Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am. J. Cardiol. 1993;71:160–165
  6. Kuusisto J, Mykkanen L, Kervinen K, Kesaniemi YA, Laakso M. Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects. Arterioscler. Thromb. Vasc. Biol. 1995;15:1280–1286
  7. Saunders AM, Roses AD. Apolipoprotein E allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease. Stroke. 1993;24:1416; [Letter]
  8. Kawamata J, Tanaka S, Shimohama S, Uede K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. J. Neurol. Neurosurg. Psychiatry. 1994;57:1414–1416
  9. Pirttilä T, Lehtimäki T, Rinne J, Mattila K, Frey H, Nikkari T. The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia. Acta Neurol. Scand. 1996;93:352–354
  10. Traykov L, Rigaud AS, Caputo L, Couderc R, Coste J, Michot JL, et al.  Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. Eur. J. Neurol. 1999;6:415–421
  11. American Psychiatric Association . Diagnostic and statistical manual of mental disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  13. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al.  Vascular dementia: diagnostic criteria for research studies (report of the NINDS-AIREN International Workshop). Neurology. 1993;43:250–260
  14. Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, et al.  Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA. 1995;273:1274–1278
  15. Bailleul S, Couderc R, Landais V, Lefevre G, Raichvarg D, Etienne J. Direct phenotyping of human Apolipoprotein E in plasma: application to population frequency distribution in Paris (France). Hum. Hered. 1993;43:159–165
  16. Harrington CR, Louwagie J, Rossau E, Vanmechelen RH, Perry EK, Xuereb JH, et al.  Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Am. J. Pathol. 1994;145:1472–1484
  17. Bowler JV, Steenhuis R, Hachinski V. Conceptual background to vascular cognitive impairment. Alzheimer Dis. Assoc. Disord. 1999;13(Suppl. 3):30–37
  18. Chui HC, Victoroff JI, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology. 1992;42:473–480
  19. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, et al.  Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study. Stroke. 1997;28:951–956
  20. Bétard C, Robitaille Y, Gee M, Tiberghien D, Larrivee D, Roy P, et al.  Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. NeuroReport. 1994;5:1893–1896
  21. Dickson DW, Roy N, Graff-Radford D, Perez-Tur J, Hardy J, Pearl G, et al.  Apolipoprotein-E genotype influences amyloid deposition and limbic neurofibrillary degeneration, but not Lewy body or vascular pathologies in postmortem brains. Neurology. 1999;52(Suppl. 2):562–563

PII: S0022-510X(02)00287-3

Journal of the Neurological Sciences
Volume 203 , Pages 177-181 , 15 November 2002

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