Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 17-21 , 15 January 2003

The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy

  • T Kiwaki

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-99-275-5332; fax: +81-99-265-7164.
    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • T. Kiwaki and F. Umehara contributed equally.
    • ,
  • F Umehara

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • T. Kiwaki and F. Umehara contributed equally.
    • ,
  • Y Arimura

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • S Izumo

      Affiliations

    • Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Disease, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • K Arimura

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • K Itoh

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • M Osame

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan

Received 29 March 2002 ,Revised 24 June 2002 ,Accepted 22 July 2002.

References 

  1. Gessain A, Barrin F, Vernant JC, et al.  Antibodies to human T-lymphotropic virus type I in patients with tropical spastic paraparesis. Lancet. 1985;2:407–409
  2. Osame M, Usuku K, Izumo S, et al.  HTLV-1 associated myelopathy, a new clinic entity. Lancet. 1986;1:1031–1032
  3. Osame M, Matsumoto M, Usuku K, et al.  Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T cell leukemia-like cell. Ann. Neurol. 1987;21:117–122
  4. Vernant JC, Maurs L, Gessain A, et al.  Endemic tropical spastic paraparesis associated with human T-lympotropic virus type: I. A clinical and seroepidemiological study of 25 cases. Ann. Neurol. 1987;21:123–130
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  8. Said G, Goulon-Goeau C, Lacriox C, et al.  Inflammatory lesions peripheral nerve in a patients with human T-lymphotropic virus type I associated myelopathy. Ann. Neurol. 1988;24:275–277
  9. Bhigjee AI, Bill PA, Wiley CA, et al.  Peripheral nerve lesions in HTLV-1 associated myelopathy (HAM/TSP). Muscle Nerve. 1993;16:21–26
  10. World Health Organization . In: Report of the scientific group on HTLV-I and associated diseases, Kagoshima, Japan, December 1988: virus disease. Human T-lymphotropic virus type I, HTLV-I. WHO Wkly. Epidemiol. Rec. vol. 49:1989;p. 382–383
  11. Kuroda Y, Sugihara H. Autopsy report of HTLV-I associated myelopathy presenting with ALS-like manifestations. J. Neurol. Sci. 1991;106:199–205
  12. Matsuzaki T, Nakagawa M, Nagai M, et al.  HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP) with amyotrophic lateral sclerosis-like manifestations. J. Neurovirol. 2000;6:544–548
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  14. Nagai M, Usuku K, Matsumoto W, et al.  Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J. Neurovirol. 1998;4:586–593
  15. Dyck PJ, Johnson WJ, Lambert EH, et al.  Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin. Proc. 1971;46:400–431
  16. Nakagawa M, Izumo S, Ijichi S, et al.  HTLV-I associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J. Neurovirol. 1995;1:50–61
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  18. Umehara F, Abe M, Kore-eda Y, et al.  Axonal damage revealed by accumulation of β-amyloid precursor protein in HTLV-I associated myelopathy. J. Neurol. Sci. 2000;176:95–101
  19. Umehara H, Izumo S, Nakagawa M, et al.  Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I associated myelopathy. J. Neuropathol. Exp. Neurol. 1993;52:424–430

PII: S0022-510X(02)00279-4

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 17-21 , 15 January 2003

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