Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 17-21, 15 January 2003

The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy

  • T Kiwaki

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-99-275-5332; fax: +81-99-265-7164.
    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • T. Kiwaki and F. Umehara contributed equally.
    • ,
  • F Umehara

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • T. Kiwaki and F. Umehara contributed equally.
    • ,
  • Y Arimura

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • S Izumo

      Affiliations

    • Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Disease, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • K Arimura

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • K Itoh

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan
    • ,
  • M Osame

      Affiliations

    • The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan

Received 29 March 2002; received in revised form 24 June 2002; accepted 22 July 2002.

Abstract 

We describe the clinical and pathological studies in HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP) patients with peripheral neuropathy as proven by sural nerve biopsy. Sural nerve pathology in HAM/TSP patients revealed that the most common type of pathologic change is a combination of both demyelination and remyelination and axonal degeneration and regeneration, and this change is modified by the complications. The pathologic changes were correlated with neither the duration of disease nor human T lymphotropic virus type I (HTLV-I) proviral load. This study suggests that peripheral nerves could be involved in HAM/TSP.

Keywords:  HTLV-I, HTLV-I associated myelopathy, Tropical spastic paraparesis, Neuropathy, Pathology

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PII: S0022-510X(02)00279-4

Journal of the Neurological Sciences
Volume 206, Issue 1 , Pages 17-21, 15 January 2003

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