Journal of the Neurological Sciences
Volume 203 , Pages 81-84 , 15 November 2002

Prevalence and clinical features of dementia associated with the antiphospholipid syndrome and circulating anticoagulants

  • Joab Chapman

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel. Tel.: +972-3-6405947; fax: +972-3-6409113.
    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Mahmoud Abu-Katash

      Affiliations

    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Rivka Inzelberg

      Affiliations

    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Israel Yust

      Affiliations

    • Department of Immunology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Miriam Y Neufeld

      Affiliations

    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Nurith Vardinon

      Affiliations

    • Department of Immunology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Therese A Treves

      Affiliations

    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Amos D Korczyn

      Affiliations

    • Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel

References 

  1. Wilson A, Gharavi AE, Koike T. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheum. 1999;42:1309–1311
  2. Levine SR, Welch KM. The spectrum of neurologic disease associated with antiphospholipid antibodies. Lupus anticoagulants and anticardiolipin antibodies. Arch. Neurol. 1987;44:876–883
  3. Brey RL. Differential diagnosis of central nervous system manifestations of the antiphospholipid antibody syndrome. J. Autoimmun. 2000;15:133–138
  4. Inzelberg R, Bornstein NM, Reider I, Korczyn AD. The lupus anticoagulant and dementia in non-SLE patients. Dementia. 1992;3:140–145
  5. Asherson RA, Mercey D, Phillips G, Sheehan N, Gharavi AE, Harris EN, et al.  Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann. Rheum. Dis. 1987;46:605–611
  6. Mosek A, Yust I, Treves TA, Vardinon N, Korczyn AD, Chapman J. Dementia and antiphospholipid antibodies. Dement. Geriatr. Cogn. Disord. 2000;11:36–38
  7. Caronti B, Calderaro C, Alessandri C, Conti F, Tinghino R, Pini C, et al.  Serum anti-beta2-glycoprotein I antibodies from patients with antiphospholipid antibody syndrome bind central nervous system cells. J. Autoimmun. 1998;11:425–429
  8. Kalashnikova LA, Korczyn AD, Shavit S, Rebrova O, Reshetnyak T, Chapman J. Antibodies to prothrombin in patients with Sneddon's syndrome. Neurology. 1999;53:223–225
  9. Maeshima E, Yamada Y, Yukawa S, Nomoto H. Higher cortical dysfunction, antiphospholipid antibodies and neuroradiological examinations in systemic lupus erythematosus. Int. Med. 1992;31:1169–1174
  10. Asherson RA, Khamashta MA, Gil A, Vazquez JJ, Chan O, Baguley E, et al.  Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am. J. Med. 1989;86:391–399 [see comments]
  11. Zvaifler NJ, Bluestein HG. The pathogenesis of central nervous system manifestations of systemic lupus erythematosus. Arthritis Rheum. 1982;25:862–866
  12. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al.  The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271–1277
  13. Hughes GR. The anticardiolipin syndrome. Clin. Exp. Rheumatol. 1985;3:285–286
  14. Shi W, Krilis SA, Chong BH, Gordon S, Chesterman CN. Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust. N. Z. J. Med. 1990;20:231–236
  15. Jude B, Goudemand J, Dolle I, Caron C, Watel A, Tiry C, et al.  Lupus anticoagulant: a clinical and laboratory study of 100 cases. Clin. Lab. Haematol. 1988;10:41–51
  16. Denburg SD, Carbotte RM, Ginsberg JS, Denburg JA. The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus. J. Int. Neuropsychol. Soc. 1997;3:377–386
  17. Harris EN. Special report. The Second International Anti-cardiolipin Standardization Workshop/the Kingston Anti-Phospholipid Antibody Study (KAPS) group. Am. J. Clin. Pathol. 1990;94:476–484
  18. Triplett DA, Brandt JT, Kaczor D, Schaeffer J. Laboratory diagnosis of lupus inhibitors: a comparison of the tissue thromboplastin inhibition procedure with a new platelet neutralization procedure. Am. J. Clin. Pathol. 1983;79:678–682
  19. Green D, Hougie C, Kazmier FJ, Lechner K, Mannucci PM, Rizza CR, et al.  Report of the working party on acquired inhibitors of coagulation: studies of the “lupus” anticoagulant. Thromb. Haemost. 1983;49:144–146
  20. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Press; 1994;
  21. Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, et al.  Cerebral blood flow in dementia. Arch. Neurol. 1975;32:632–637
  22. Treves TA, Ragolsky M, Gelentner I, Korczyn AD. Evaluation of a short mental test for the diagnosis of dementia. Dementia. 1990;1:102–108
  23. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, et al.  Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989;262:2551–2556 [see comments]
  24. Levine SR, Brey RL, Sawaya KL, Salowich-Palm L, Kokkinos J, Kostrzema B, et al.  Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. Ann. Neurol. 1995;38:119–124
  25. Chapman J, Cohen-Armon M, Shoenfeld Y, Korczyn AD. Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes. Lupus. 1999;8:127–133
  26. Siemens H-JG, Gutsche S, Bruckner S, Bucsky P, Katus HA. Antiphospholipid antibodies in children without and in adults with and without thrombophilia. Thromb. Res. 2000;98:241–247

PII: S0022-510X(02)00271-X

Journal of the Neurological Sciences
Volume 203 , Pages 81-84 , 15 November 2002

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