Remyelination in multiple sclerosis

(a) Remyelinated lesion in the dorsal funiculus of adult rat spinal cord 3 weeks after induction of demyelination with 1% lysolecithin. Uniformly thin myelin sheaths are detectable with a decreased myelin thickness to axon diameter ratio. (b) Late remyelinated shadow plaque with myelin pallor and a sharp border to the normal appearing white matter (immunocytochemistry for MBP). (c) Early remyelinating lesion with irregularly arranged thin myelin sheaths that surround clusters of axons. Note the high cellularity in the lesion at this stage of early remyelination (immunocytochemistry for MBP).