Journal of the Neurological Sciences
Volume 201, Issue 1 , Pages 85-88, 15 September 2002

Successful immune treatment for non-paraneoplastic limbic encephalitis

  • Masahiro Mori

      Affiliations

    • Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-43-222-2129; fax: +81-43-226-2160
    • ,
  • Satoshi Kuwabara

      Affiliations

    • Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Mitsuharu Yoshiyama

      Affiliations

    • Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Toshihide Kanesaka

      Affiliations

    • Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Tsuyoshi Ogata

      Affiliations

    • Department of Psychology, Chuo University, Tokyo, Japan
    • ,
  • Takamichi Hattori

      Affiliations

    • Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan

Received 21 March 2002; accepted 28 May 2002.

Abstract 

A 21-year-old woman subacutely developed memory loss subsequent to gastroenteritis. Brain MRI with gadolinium enhancement showed symmetric involvement of the amygdala. The CSF was acellular with increased protein level. There was no evidence suggestive of neoplasm or viral infection. Combined treatment with plasmapheresis and immunoglobulin improved her clinical symptoms and lessened abnormalities manifested in the MRI. This case suggests the presence of immune-mediated limbic encephalitis without association with neoplasms or infections.

Keywords:  Limbic encephalitis, Autoimmune disease, Plasmapheresis

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PII: S0022-510X(02)00188-0

Journal of the Neurological Sciences
Volume 201, Issue 1 , Pages 85-88, 15 September 2002

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