Journal of the Neurological Sciences
Volume 201, Issue 1 , Pages 9-12 , 15 September 2002

Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome

  • Masami Tanaka

      Affiliations

    • Corresponding Author InformationCorresponding author. Fax: +81-25-231-2831
    • Department of Neurology and Clinical Research Center, National Nishi-Niigata Central Hospital, 1-14-1 Masago, Niigata 950-2085, Japan
    • ,
  • Yoshie Maruyama

      Affiliations

    • Department of Respiratory Medicine, National Nishi-Niigata Central Hospital, Japan
    • ,
  • Miho Sugie

      Affiliations

    • Department of Neurology, Nara Prefectural Hospital, Nara, Japan
    • ,
  • Hitoshi Motizuki

      Affiliations

    • Third Department of Internal Medicine, National Defence Medical College, Tokorozawa, Japan
    • ,
  • Keiko Kamakura

      Affiliations

    • Third Department of Internal Medicine, National Defence Medical College, Tokorozawa, Japan
    • ,
  • Keiko Tanaka

      Affiliations

    • Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

Received 7 December 2001 ,Revised 8 April 2002 ,Accepted 20 May 2002.

References 

  1. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain. 2000;123:1481–1494
  2. Dalmau J, Furneaux HM, Rosenblum MK, Graus F, Posner JB. Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Neurology. 1991;41:1757–1764
  3. Dalmau J, Gultekin SH, Voltz R, Hoard R, DesChamps T, Balmaceda C, et al.  Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain. 1999;122:27–39
  4. Voltz R, Humayun Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB, et al.  A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. N. Engl. J. Med. 1999;340:1788–1795
  5. Buckley C, Oger J, Clover L, Tuzun E, Carpenter K, Jackson M, et al.  Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann. Neurol. 2001;50:73–78
  6. Rosenbaum T, Gartner J, Korholz D, Janssen G, Schneider D, Engelbrecht V, et al.  Paraneoplastic limbic encephalitis in two teenage girls. Neuropediatrics. 1998;29:159–162
  7. Moll JW, Antoine JC, Brashear HR, Delattre J, Drlicek M, Dropcho EJ, et al.  In: Guidelines on the detection of paraneoplastic anti-neuronal-specific antibodies: report from the Workshop to the Fourth Meeting of the International Society of Neuro-Immunology on paraneoplastic neurological disease, held October 22–23, 1994, in Rotterdam, The Netherlands. Neurology. vol. 45:1995;p. 1937–1941
  8. Vega F, Graus F, Chen QM, Poisson M, Schuller E, Delattre JY. Intrathecal synthesis of the anti-Hu antibody in patients with paraneoplastic encephalomyelitis or sensory neuronopathy: clinical–immunologic correlation. Neurology. 1994;44:2145–2147
  9. Rauer S, Kaiser R. Demonstration of anti-HuD specific oligoclonal bands in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Qualitative evidence of anti-HuD specific IgG-synthesis in the central nervous system. J. Neuroimmunol. 2000;111:241–244
  10. Brashear HR, Caccamo DV, Heck A, Koeney PM. Localization of antibody in the central nervous system of a patient with paraneoplastic encephalomyeloneuritis. Neurology. 1991;41:1583–1587
  11. Greenlee JE, Parks TN, Jaeckle KA. Type IIa (‘anti-Hu’) antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology. 1993;43:2049–2054
  12. Hormigo A, Lieberman F. Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity. J. Neuroimmunol. 1994;55:205–212
  13. Sillevis Smitt PA, Manley GT, Posner JB. Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. Neurology. 1995;45:1873–1878
  14. Graus F, Ribalta T, Campo E, Monforte R, Urbano A, Rozman C. Immuno-histochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis. Neurology. 1990;40:219–222
  15. Jean WC, Dalmau J, Ho A, Posner JB. Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology. 1994;44:140–147
  16. Tanaka K, Tanaka M, Inuzuka T, Nakano R, Tsuji S. Cytotoxic T lymphocyte-mediated cell death in paraneoplastic sensory neuronopathy with anti-Hu antibody. J. Neurol. Sci. 1999;163:159–162
  17. Davenport MP, Hill AVS. Reverse immunogenetics: from HLA-disease associations to vaccine candidates. Mol. Med. Today. 1996;2:38–45
  18. Tanaka M, Tanaka K, Tokiguchi S, Shinozawa K, Tsuji S. Cytotoxic T cells against a peptide from Yo protein in patients with paraneoplastic cerebellar degeneration with anti-Yo antibody. J. Neuroimmunol. 1998;90:102
  19. Albert ML, Darnell JC, Bender A, Francisco LM, Bhardwaj N, Darnell RB. Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat. Med. 1998;4:1321–1324
  20. Tanaka M, Tanaka K. HLA A24 in paraneoplastic cerebellar degeneration with anti-Yo antibody. Neurology. 1996;47:606–607
  21. Tanaka M, Tanaka K, Tokiguchi S, Shinozawa K, Tsuji S. Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody. J. Neurol. Sci. 1999;168:28–31
  22. Kawachi I, Tanaka K, Tanaka M, Tsuji S. Dendritic cells presenting pyruvate kinase M1/M2 isozyme peptide can induce experimental allergic myositis in BALB/c mice. J. Neuroimmunol. 2001;117:108–115
  23. Sette A, Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and-B polymorphism. Immunogenetics. 1999;50:201–212
  24. Tanaka M, Tanaka K, Miyamoto N, Kamakura K. A peptide with the binding motif for the HLA B7 supertype reacts with CD8 positive cytotoxic T cells in anti-Hu syndrome. Biomed. Res. 2000;21:25–29
  25. Tanaka M, Tanaka K, Tsuji S, Kawata A, Kojima S, Kurokawa T, et al.  Cytotoxic T cell activity against the peptide, AYRARALEL, from Yo protein of patients with the HLA A24 or B27 supertype and paraneoplastic cerebellar degeneration. J. Neurol. Sci. 2001;188:61–65
  26. Benyahia B, Liblau R, Merle-Beral H, Tourani JM, Dalmau J, Delattre JY. Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. Ann. Neurol. 1999;45:162–167
  27. Voltz R, Dalmau J, Posner JB, Rosenfeld MR. T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology. 1998;51:1146–1150
  28. Plonquet A, Gherardi RK, Créange A, Antoine JC, Benyahia B, Grisold W, et al.  Oligoclonal T-cells in blood and target tissues of patients with anti-Hu syndrome. J. Neuroimmunol. 2002;122:100–105
  29. Hayashi M, Kohno T, Yoshinaga J, Kido K. Epitope analysis of AchR ab in patients with myasthenia gravis using sensitive enzyme immunoassay. Ann. N. Y. Acad. Sci. 1998;841:478–481

PII: S0022-510X(02)00157-0

Journal of the Neurological Sciences
Volume 201, Issue 1 , Pages 9-12 , 15 September 2002

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