Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 53-55 , 15 August 2002

Serial analysis of cytokine mRNA profiles in whole blood samples from patients with early multiple sclerosis

  • K.G Kahl

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Ratzeburger Allee 160, 23538 Lübeck, Germany. Tel.: +49-451-500-2921; fax: +49-451-500-2603
    • ,
  • N Kruse
    • ,
  • K.V Toyka
    • ,
  • P Rieckmann

Received 23 July 2001 ,Revised 29 March 2002 ,Accepted 2 May 2002.

References 

  1. Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wietzerbin J. Increased production of interferon-gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?. Acta Neurol. Scand. 1988;78:318–326
  2. Rieckmann P, Albercht M, Kitze B, Weber T, Tumani H, Broocks A, et al.  Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing–remitting multiple sclerosis is associated with disease activity. Ann. Neurol. 1995;37:82–88
  3. Arya SK, Wong S, Gallo RC. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon mRNA. J. Immunol. 1984;133:273–276
  4. Han J, Thompson M, Beutler B. Dexamethasone and pentoxifilline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J. Exp. Med. 1990;172:391–395
  5. Kruse N, Pette M, Toyka K, Rieckmann P. Quantification of cytokine mRNA expression by reverse transcriptase PCR in samples of previously frozen blood. J. Immunol. Methods. 1997;210:195–203
  6. Poser CM, Paty DW, Scheinberg L, et al.  New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983;13:227–231
  7. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al.  Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001;50:121–127
  8. Calabresi PA, Tranquill LR, McFarland HF, Cowan EP. Cytokine gene expression in cells derived from CSF of multiple sclerosis patients. J. Neuroimmunol. 1998;89:198–205
  9. Monteyne P, Cindic CJ. Data on cytokine mRNA expression in CSF and peripheral blood mononuclear cells from MS patients as detected by PCR. Mult. Scler. 1998;4:143–146
  10. Vandevyver C, Motmans K, Stinissen P, Zhang J, Raus J. Cytokine mRNA profile of myelin-basic protein reactive T-cell clones in patients with multiple sclerosis. Autoimmunity. 1998;28:77–78
  11. Bitsch A, Kuhlmann T, Da Costa C, Bunkowski S, Polak T, Bruck W. Tumor necrosis factor alpha mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology. Glia. 2000;29:366–375
  12. Brosnan CF, Raine CS. Mechanisms of immune injury in multiple sclerosis. Brain Pathol. 1996;6:243–257
  13. Navikas V, Link H. Review: cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 1996;45:322–333
  14. Olsson T. Multiple sclerosis: cerebrospinal fluid. Ann. Neurol. 1994;36:S100–102
  15. Ramirez F, Fowell DJ, Puklavec M, Mason D. Glucocorticoids promote a Th2 cytokine response by CD4+ T-cells in vitro. J. Immunol. 1996;156:2406–2412
  16. Gayo A, Mozo L, Suarez A, Lahoz C, Gutierrez C. Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse. J. Neuroimmunol. 1998;85:122–130
  17. Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann. Neurol. 1997;42:313–318
  18. van Boxel-Dezaire AH, Hoff SC, van Oosten BW, Verweij CL, Drager AM, Ader HJ, et al.  Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis. Ann. Neurol. 1999;45:695–703
  19. Correale J, Gilmore W, Mc Millan M. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T-cell clones during the course of multiple sclerosis. J Immunol. 1995;154:2959–2968
  20. Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Broocks A, et al.  Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology. 1994;44:1523–1526

PII: S0022-510X(02)00136-3

Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 53-55 , 15 August 2002

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