Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 27-32 , 15 August 2002

Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease

  • Setsu Sakamoto

      Affiliations

    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • ,
  • Kazunari Ishii

      Affiliations

    • Corresponding Author InformationCorresponding author. Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko, Himeji, Hyogo 670-0981, Japan. Tel.: +81-792-95-5511; fax: +81-792-95-8199
    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • ,
  • Masahiro Sasaki

      Affiliations

    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • ,
  • Kayo Hosaka

      Affiliations

    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • Department of Radiology, Kobe University School of Medicine, Kobe, Hyogo, Japan
    • ,
  • Tetsuya Mori

      Affiliations

    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • ,
  • Mieko Matsui

      Affiliations

    • Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), 520 Saisho-Ko Himeji, Hyogo 670-0981, Japan
    • ,
  • Nobutsugu Hirono

      Affiliations

    • Division of Neurosciences,Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), Himeji, Hyogo, Japan
    • ,
  • Etsuro Mori

      Affiliations

    • Division of Neurosciences,Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), Himeji, Hyogo, Japan

Received 5 February 2002 ,Revised 19 April 2002 ,Accepted 22 April 2002.

References 

  1. Minoshima S, Ficaro EP, Frey KA, Koeppe RA, Kuhl DE. Data extraction from brain PET images using three-dimensional stereotactic surface projections. In:  Carson RE,  Daube-Witherspoon ME,  Herscovitch P editor. Quantitative functional brain imaging with positron emission tomography. New York: Academic Press; 1998;p. 133–137
  2. Small GW, Kuhl DE, Riege WH, et al.  Cerebral glucose metabolic patterns in Alzheimer's disease. Effect of gender and age at dementia onset. Arch. Gen. Psychiatry. 1989;46:527–532
  3. Grady CL, Haxby JV, Horwitz B, Berg G, Rapoport SI. Neuropsychological and cerebral metabolic function in early vs late onset dementia of the Alzheimer type. Neuropsychologia. 1987;25:807–816
  4. Jagust WJ, Reed BR, Seab JP, Bundinger TF. Age at onset and single photon emission computed tomographic patterns of regional cerebral blood flow. Arch. Neurol. 1990;47:628–633
  5. Mielke R, Herholz K, Grond M, Kessler J, Heiss WD. Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type. Neurobiol. Aging. 1992;13:93–98
  6. Caffarra P, Scaglioni A, Malvezzi L, Previdi P, Spreafico L, Salmaso D. Age at onset and SPECT imaging in Alzheimer's disease. Dementia. 1993;4:342–346
  7. Ichimiya A, Herholz K, Mielke R, Kessler J, Slansky I, Heiss WD. Difference of regional cerebral metabolic pattern between presenile and senile dementia of the Alzheimer type: a factor analytic study. J. Neurol. Sci. 1994;123:11–17
  8. Yasuno F, Imamura T, Hirono N, et al.  Age at onset and regional cerebral glucose metabolism in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 1998;9:63–67
  9. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiat. Res. 1975;12:189–198
  10. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS/ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's disease. Neurology. 1984;34:939–944
  11. Ishii K, Sasaki M, Kitagaki H, Sakamoto S, Yamaji S, Maeda K. Regional difference of cerebral blood flow and oxidative metabolism in human cortex. J. Nucl. Med. 1996;37:1086–1088
  12. Ishii K, Sasaki M, Kitagaki H, et al.  Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease. J. Nucl. Med. 1997;38:925–928
  13. Sakamoto S, Ishii K. Low cerebral glucose extraction rates in the human medial temporal cortex and cerebellum. J. Neurol. Sci. 2000;172:41–48
  14. Iida H, Miura S, Kanno I, et al.  Design of evaluation of Headtome IV: a whole body positron emission tomograph. IEEE Trans. Nucl. Sci. 1989;NS-37:1006–1010
  15. Ishii K, Willoch F, Minoshima S, Drzezga A, Ficaro EP, Cross DJ, et al.  Statistical brain mapping of FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains. J. Nucl. Med. 2001;42:548–557
  16. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme Verlag; 1988;
  17. Minoshima S, Berger KL, Lee KS, Mintun MA. An automated method for rotational correction and centering of three-dimensional functional brain images. J. Nucl. Med. 1992;33:1579–1585
  18. Minoshima S, Koeppe RA, Mintun MA, et al.  Automated detection of the intercommissural line for stereotactic localization of functional brain images. J. Nucl. Med. 1993;34:322–329
  19. Minoshima S, Koeppe RA, Frey KA, Kuhl DE. Anatomical standardization: linear scaling and nonlinear warping of functional brain images. J. Nucl. Med. 1994;35:1528–1537
  20. Friston KJ, Holmes AP, Worsely KJ, Poline JB, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp. 1995;2:189–210
  21. Friedland RP, Budinger TF, Ganz E, et al.  Regional cerebral metabolic alteration in dementia of the Alzheimer type: PET with [18F] fluorodeoxyglucose. J. Comput. Assist. Tomogr. 1983;7:590–598
  22. Foster NL, Chase TN, Fedio P, Patronas NJ, Brooks BA, DiChoir G. Alzheimer's disease: focal cortical changes shown by positron emission tomography. Neurology. 1983;33:961–965
  23. Kuhl DE. Imaging local brain function with positron emission tomography. Radiology. 1984;150:625–631
  24. Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer's disease. Lancet. 1994;344:895
  25. Ishii K, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Mori E. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography. Eur. J. Nucl. Med. 1997;24:670–673
  26. Salmon E, Collette F, Degueldre C, Lemaire C, Franck G. Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease. Hum. Brain Mapp. 2000;10:39–48
  27. Jacobs D, Sano M, Marder K, et al.  Age at onset of Alzheimer's disease: relation to pattern of cognitive dysfunction and rate of decline. Neurology. 1994;44:1215–1220
  28. Coleman PD, Flood DG. Neuron number and dendritic extent in normal aging and Alzheimer's disease. Neurobiol. Aging. 1987;8:521–545
  29. Ball MJ. Neuronal loss, neurofibrillary tangles and granulovascular degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol. 1977;37:111–118

PII: S0022-510X(02)00114-4

Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 27-32 , 15 August 2002

Article Tools

* Image Usage & Resolution