Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 33-41 , 15 August 2002

Treatment of spinal cord impact injury in the rat with transforming growth factor-β

  • William R Tyor

      Affiliations

    • Corresponding Author InformationCorresponding author. Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401, USA. Tel.: +1-843-789-7428; fax: +1-843-937-6110
    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Nicholas Avgeropoulos

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • Current address: Neurooncology Center,WDMCI at Florida Hospital, Suite 581, 2501 N. Orange Avenue, Orlando, FL 32804, USA.
    • ,
  • George Ohlandt

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Edward L Hogan

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA

Received 8 February 2002 ,Revised 19 April 2002 ,Accepted 22 April 2002.

References 

  1. Tator CH. Experimental and clinical studies of the pathophysiology and management of acute spinal cord injury. J. Spinal Cord Med. 1996;19:206–216
  2. Popovich PG, Reinhard JF, Flanagan EM, Stokes BT. Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma. Brain Res. 1994;633:348–352
  3. Li Z, Hogan EL, Banik NL. Role of calpain in spinal cord injury: increased calpain immunoreactivity in rat spinal cord after impact trauma. Neurochem. Res. 1996;21:441–448
  4. Xu J, Hsu CY, Junker H, et al.  Kininogen and kinin in experimental spinal cord injury. J. Neurochem. 1991;57:975–980
  5. Ransohoff RM. Chemokines in neurological disease models: correlation between chemokine expression patterns and inflammatory pathology. J. Leukoc. Biol. 1997;62:645–652
  6. McTigue DM, Tani M, Krivacic K, et al.  Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. J. Neurosci. Res. 1998;53:368–376
  7. Yakovlev AG, Faden AI. Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury. Mol. Chem. Neuropathol. 1994;23:179–190
  8. Wang CX, Nuttin B, Heremans H, Dom R, Gybels J. Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J. Neuroimmunol. 1996;69:151–156
  9. Klusman I, Schwab ME. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 1997;762:173–184
  10. Tyor WR. Fundamentals of immunology. In:  Rolak LA,  Harati Y editor. Neuroimmunology for the Clinician. Boston, MA, USA: Butterworth-Heineman; 1997;p. 3–33
  11. Selmaj KW, Raine CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 1988;23:339–346
  12. Soliven B, Albert J. Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons. J. Neurosci. 1992;12:2665–2671
  13. Racke MK, Dhib-Jalbut S, Cannella B, et al.  Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-b1. J. Immunol. 1991;146:3012–3017
  14. O'Brien MF, Lenke LG, Lou J, Bridwell KH, Joyce ME. Astrocyte response and transforming growth factor-b localization in acute spinal cord injury. Spine. 1994;20:2321–2330
  15. Semple-Rowland SL, Mahatme A, Popovich PG, et al.  Analysis of TGF-beta 1 gene expression in contused rat spinal cord using quantitative RT-PCR. J. Neurotrauma. 1995;12:1003–1014
  16. Hamada Y, Ikata T, Katoh S, et al.  Effects of exogenous transforming growth factor-beta 1 on spinal cord injury in rats. Neurosci. Lett. 1996;203:97–100
  17. Wesselingh S, Power CC, Glass JD, et al.  Intracerebral cytokine mRNA expression in AIDS dementia. Ann. Neurol. 1993;33:576–582
  18. Tyor WR, Glass J, Becker S, et al.  Cytokine expression in the brain during AIDS. Ann. Neurol. 1992;31:349–360
  19. Balabanov R, Dore-Duffy P. Role of the CNS microvascular pericyte in the blood–brain barrier. J. Neurosci. Res. 1998;53:637–644
  20. Feuerstein GZ, Lui T, Barone FC. Cytokines, inflammation and brain injury: role of tumor necrosis factor-alpha. Cerebrovasc. Brain Metab. Rev. 1994;6:341–360
  21. Shohami E, Novikov M, Bass R, Yamin A, Gallily R. Closed head injury triggers early producion of TNFa and IL-6 by brain tissue. J. Cereb. Blood Flow Metab. 1994;14:615–619
  22. Aloisi F, De Simone R, Columba-Caezas S, Levi G. Opposite effects of interferon-γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activities. J. Neurosci. Res. 1999;56:571–580
  23. Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, et al.  A mettaloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997;385:729
  24. Grande JP. Role of transforming growth factor-b in tissue injury and repair. P. Soc. Exp. Biol. Med. 1997;214:27–40
  25. da Cunha A, Jefferson JJ, Tyor WR, et al.  Control of astrocytes by interleukin-1 and transforming growth factor-b1 in human brain. Brain Res. 1993;631:39–45
  26. Takeuchi M, Alard P, Streilein JW. TGF-b promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 1998;160:1589–1597
  27. Kitamura M. Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-b1. J. Immunol. 1997;159:1404–1411
  28. Warwick-Davies J, Lowrie DB, Cole PJ. Selective deactivation of human monocyte functions by TGF-b. J. Immunol. 1995;155:3186–3193

PII: S0022-510X(02)00113-2

Journal of the Neurological Sciences
Volume 200, Issue 1 , Pages 33-41 , 15 August 2002

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