Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 37-41 , 15 June 2002

Reduction in metabolite transverse relaxation times in amyotrophic lateral sclerosis

  • Christopher C. Hanstock

      Affiliations

    • Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, T6G 2G2
    • Corresponding Author InformationCorresponding author. Tel.: +1-780-492-2542; fax: +1-780-492-8259
    • ,
  • Valerie A. Cwik

      Affiliations

    • Department of Neurology, University of Arizona, Tucson, AZ, USA
    • ,
  • W.R.Wayne Martin

      Affiliations

    • Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada

Received 22 October 2001 ,Revised 11 February 2002 ,Accepted 5 March 2002.

References 

  1. Mason GF, Pohost GM, Hetherington HP. Numerically optimized experiment design for measurement of grey/white matter metabolite T2 in high-resolution spectroscopic images of brain. J. Magn. Reson., Ser. B. 1995;107(1):68–73
  2. Hanstock CC, Allen PS. Applications of proton MRS to study human brain metabolism. In:  Boulton AA,  Baker GB,  Bateson AN editor. Neuromethods: Cell Neurobiology Techniques, Chap. 11. vol. 33:Totowa, New Jersey, USA: Humana Press; 1998;p. 347–380
  3. Kamada K, Houkin K, Hida K, Matsuzawa H, Iwasaki Y, Abe H, et al. Localized proton spectroscopy of focal brain pathology in humans: significant effects of edema on spin–spin relaxation time. Magn. Reson. Med. 1994;31(5):537–540
  4. Cwik VA, Hanstock CC, Allen PS, Martin WRW. Estimation of brainstem neuronal loss in amyotrophic lateral sclerosis by in vivo proton magnetic resonance spectroscopy. Neurology. 1998;50(1):72–77
  5. Toft PB, Christiansen P, Pryds O, Lou HC, Henriksen O. T1, T2, and concentrations of brain metabolites in neonates and adolescents estimated with H-1 MR spectroscopy. J. Magn. Reson. Imag. 1994;4(1):1–5
  6. Christiansen P, Toft P, Larsson HB, Stubgaard M, Henriksen O. The concentration of N-acetyl aspartate, creatine+phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn. Reson. Imag. 1993;11(6):799–806
  7. Payen JF, LeBars E, Wuyam B, Tropini B, Pepin JL, Levy P, et al. Lactate accumulation during moderate hypoxic hypoxia in neocortical rat brain. J. Cereb. Blood Flow Metab. 1996;16(6):1345–1352
  8. Van der Toorn A, Dijkhuizen RM, Tulleken CA, Nicolay K. T1 and T2 relaxation times of the major 1H-containing metabolites in rat brain after focal ischemia. NMR Biomed. 1995;8(6):245–252
  9. Kuhmonen J, Sivenius J, Riekkinen PJ, Kauppinen RA. Decrease in brain choline-containing compounds following a short period of global ischemia in gerbils as detected by 1H NMR spectroscopy in vivo. NMR Biomed. 1994;7(5):231–236
  10. Sappey-Marinier D, Calabrese G, Hetherington HP, Fisher SN, Deicken R, Van Dyke C, et al. Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. Magn. Reson. Med. 1992;26(2):313–327
  11. Cheung G, Gawel MJ, Cooper PW, Farb RI, Ang LC, Gawel MJ. Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology. 1995;194(1):263–270
  12. Abe K, Fujimura H, Kobayashi Y, Fujita N, Yanagihara T. Degeneration of the pyramidal tracts in patients with amyotrophic lateral sclerosis. A premortem and postmortem magnetic resonance imaging study. J. Neuroimag. 1997;7(4):208–212
  13. Terao S, Sobue G, Yasuda T, Kachi T, Takahashi M, Mitsuma T. Magnetic resonance imaging of the corticospinal tracts in amyotrophic lateral sclerosis. J. Neurol. Sci. 1995;133(1–2):66–72
  14. Block W, Karitzky J, Traber F, Pohl C, Keller E, Mundegar RR, et al. Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch. Neurol. 1998;55(7):931–936

PII: S0022-510X(02)00074-6

Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 37-41 , 15 June 2002

Article Tools

* Image Usage & Resolution