Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders

Ohkubo, Ryuichi; Nakagawa, Masanori; Ikeda, Ken-ichi; Kodama, Tomoko; Arimura, Kimiyoshi; Akiba, Suminori; Saito, Minoru; Ookatsu, Yosuke; Atsuchi, Yoshihiko; Yamano, Yoshihisa; Osame, Mitsuhiro

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Volume 198, Issue 1 , Pages 31-35, 15 June 2002

Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders

Ryuichi Ohkubo
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan
Masanori Nakagawa
- Corresponding author. Tel.: +81-992-75-5332; fax: +81-992-65-7164
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan
Ken-ichi Ikeda
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan
Tomoko Kodama
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan
- Department of Public Health, Kagoshima University Faculty of Medicine, Kagoshima, Japan
Kimiyoshi Arimura
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan
Suminori Akiba
- Department of Public Health, Kagoshima University Faculty of Medicine, Kagoshima, Japan
Minoru Saito
- Division of Neurology, Ookatsu Hospital, Kagoshima, Japan
Yosuke Ookatsu
- Division of Neurology, Ookatsu Hospital, Kagoshima, Japan
Yoshihiko Atsuchi
- Division of Internal Medicine, Tenyokai Chuo Hospital, Kagoshima, Japan
Yoshihisa Yamano
- Division of Internal Medicine, Tenyokai Chuo Hospital, Kagoshima, Japan
Mitsuhiro Osame
- Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8520, Japan

Received 2 October 2001; received in revised form 27 February 2002; accepted 28 February 2002.

Abstract

We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls (P<0.01). The frequency of DCP1 insertion (I) and deletion (D) alleles showed no significant difference between the CVD patients and controls or between each CVD subgroup. Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD.

Keywords: Cerebrovascular disorders, ACE, Mitochondrial DNA, Aging, Risk factors