Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 97-100, 15 June 2002

Lewy body-free nigral degeneration—a case report

  • Kenji Ishihara

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-03-3784-8781; fax: +81-03-3784-1936
    • Department of Neurology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8666, Japan
    • ,
  • Akiko Nonaka

      Affiliations

    • Department of Neurology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8666, Japan
    • ,
  • Toshiya Fukui

      Affiliations

    • Department of Neurology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8666, Japan
    • ,
  • Mitsuru Kawamura

      Affiliations

    • Department of Neurology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8666, Japan
    • ,
  • Jun-ichi Shiota

      Affiliations

    • Department of Neurology, Ushioda General Hospital, Yokohama, Japan
    • ,
  • Imaharu Nakano

      Affiliations

    • Department of Neurology, Jichi Medical School, Tochigi, Japan

Received 31 December 2001; accepted 25 February 2002.

Abstract 

A 70-year-old Japanese woman developed progressive, dopa-responsive parkinsonism consisting of akinesia, resting tremor, rigidity, and postural instability. Neuropathological examination revealed a marked loss of nigral neurons, but no Lewy bodies (LBs) were observed. Lewy bodies were also absent from their usual site, with the exception of a small number seen in the dorsal motor nucleus of the vagus nerve (DVN) and sympathetic ganglion. We propose that our case and several similar reported cases represent Lewy body-free nigral degeneration.

Keywords:  Parkinsonism, Substantia nigra, Lewy body

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PII: S0022-510X(02)00050-3

Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 97-100, 15 June 2002

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