Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 9-15 , 15 June 2002

l-Arginine/nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content

  • Paola Sarchielli

      Affiliations

    • Corresponding Author InformationCorresponding author. Neurological Clinic, University of Perugia, Via E. Dal Pozzo 79, 06126 Perugia, Italy. Tel.: +39-075-578-3871; fax: +39-075-578-3583
    • Interuniversity Center for the Study of Headache and Neurotransmitter Disorders, Perugia, Rome, Sassari, Bari, Naples, Florence—Unit of Perugia, Perugia, Italy
  • ,
  • Andrea Alberti

      Affiliations

    • Interuniversity Center for the Study of Headache and Neurotransmitter Disorders, Perugia, Rome, Sassari, Bari, Naples, Florence—Unit of Perugia, Perugia, Italy
  • ,
  • Ardesio Floridi

      Affiliations

    • Department of Internal Medicine, Institute of Clinical and Applied Biochemistry, University of Perugia, Perugia, Italy
  • ,
  • Virgilio Gallai

      Affiliations

    • Interuniversity Center for the Study of Headache and Neurotransmitter Disorders, Perugia, Rome, Sassari, Bari, Naples, Florence—Unit of Perugia, Perugia, Italy

Received 8 August 2001 ,Revised 1 November 2001 ,Accepted 5 February 2002.

References 

  1. Ashina M, Lassen LH, Bendtsen L, Jensen R, Olesen J. Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial. Lancet. 1999;353(9149):287–289
  2. Ashina M, Bendtsen L, Jensen R, Lassen LH, Sakai F, Olesen J. Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache. Brain. 1999;122(Pt 9):1629–1635
  3. Ashina M, Bendtsen L, Jensen R, Olesen J. Nitric oxide — induced headache in patients with chronic tension-type headache. Brain. 2000;123(Pt 9):1830–1837
  4. D'Andrea G, Cananzi AR, Perini F, Hasselmark L. Platelet models and their possible usefulness in the study of migraine pathogenesis. Cephalalgia. 1995;15(4):265–271
  5. Radomski MW, Palmer RM, Moncada S. An l-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci.U.S.A. 1990;87(13):5193–5197
  6. Sarchielli P, Alberti A, Russo S, Codini M, Panico R, Floridi A, et al. Nitric oxide pathway, Ca2+, and serotonin content in platelets from patients suffering from chronic daily headache. Cephalalgia. 1999;19(9):810–816
  7. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(Suppl. 7):1–96
  8. Silberstein SD, Lipton RB, Solomon S, Mathew NT. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994;34(1):1–7
  9. Silberstein SD, Lipton RB, Sliwinski M. Classification of daily and near-daily headaches: field trial of revised IHS criteria. Neurology. 1996;47(4):871–875
  10. Born GVR, Cross MJ. The aggregation of blood platelets. J. Physiol. 1963;168:178–195
  11. Astarie-Dequeker C, Iouzalen L, David-Dufilho M, Devynck MA. In vitro inhibition by endothelins of thrombin-induced aggregation and Ca2+ mobilization in human platelets. Br. J. Pharmacol. 1992;106(4):966–971
  12. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985;260(6):3440–3450
  13. Zecca L, Ferrario P. Determination of neurotransmitter amino acids by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 1985;337(2):391–396
  14. Meller ST, Gebhart GF. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. 1993;52(2):127–136
  15. Hao JX, Xu XJ. Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors. Pain. 1996;66(2-3):313–319
  16. Hoskin KL, Bulmer DC, Goadsby PJ. Fos expression in the trigeminocervical complex of the cat after stimulation of the superior sagittal sinus is reduced by l-NAME. Neurosci. Lett. 1999;266(3):173–176
  17. Kitto KF, Haley JE, Wilcox GL. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse. Neurosci. Lett. 1992;148(1-2):1–5
  18. Bendtsen L. Central sensitization in tension-type headache-possible pathophysiological mechanisms. Cephalalgia. 2000;20(5):486–508
  19. Bendtsen L, Jensen R, Hindberg I, Gammeltoft S, Olesen J. Serotonin metabolism in chronic tension-type headache. Cephalalgia. 1997;17(8):843–848
  20. Bendtsen L, Mellerup ET. The platelet serotonin transporter in primary headaches. Eur. J. Neurol. 1998;5(3):277–282
  21. Srikiatkhachorn A, Anthony M. Platelet serotonin in patients with analgesic-induced headache. Cephalalgia. 1996;16(6):423–426
  22. Kudrow L. Possible mechanisms and treatment of analgesic-induced chronic headache. In:  Diener HC,  Wilkinson M editor. Drug-induced headache. Berlin: Springer-Verlag; 1988;p. 157–161
  23. Srikiatkhachorn A, Tarasub N, Govitrapong P. Effect of chronic analgesic exposure on the central serotonin system: a possible mechanism of analgesic abuse headache. Headache. 2000;40(5):343–350
  24. Cananzi AR, D'Andrea G, Perini F, Zamberlan F, Welch KM. Platelet and plasma levels of glutamate and glutamine in migraine with and without aura. Cephalalgia. 1995;15(2):132–135
  25. Harris JA, Corsi M, Quartaroli M, Arban R, Bentivoglio M. Upregulation of spinal glutamate receptors in chronic pain. Neuroscience. 1996;74(1):7–12
  26. Baranauskas G, Nistri A. Sensitization of pain pathways in the spinal cord: cellular mechanisms. Prog. Neurobiol. 1998;54(3):349–365
  27. Felsby S, Nielsen J, Arendt-Nielsen L, Jensen TS. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain. 1996;64(2):283–291
  28. Urban MO, Gebhart GF. Central mechanisms in pain. Med. Clin. North Am. 1999;83(3):585–596

PII: S0022-510X(02)00035-7

Journal of the Neurological Sciences
Volume 198, Issue 1 , Pages 9-15 , 15 June 2002