Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 71-74 , 15 February 2002

Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study

  • M Codella

      Affiliations

    • Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    • ,
  • M.A Rocca

      Affiliations

    • Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    • ,
  • B Colombo

      Affiliations

    • Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    • ,
  • F Martinelli-Boneschi

      Affiliations

    • Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    • ,
  • G Comi

      Affiliations

    • Clinical Trials Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    • ,
  • M Filippi

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +39-2-2643-3032; fax: +39-2-2643-3054
    • Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy

Received 26 June 2001 ,Revised 6 September 2001 ,Accepted 26 November 2001.

References 

  1. Krupp LB, Alvarez LA, La Rocca NG, Scheinberg LC. Clinical characteristics of fatigue in multiple sclerosis. Arch. Neurol. 1988;45:435–437
  2. van der Werf SP, Jogen PJH, Lycklama à Nijeholt GJ, Barkhof F, Hommes OR, Bleijenberg G. Fatigue in multiple sclerosis: interrelations between fatigue complaints, cerebral MRI abnormalities and neurological disability. J. Neurol. Sci. 1998;160:164–170
  3. Bakshi R, Miletich RS, Henschel K, et al.  Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patients. Neurology. 1999;53:1151–1153
  4. Mainero C, Faroni J, Gasperini C, et al.  Fatigue and magnetic resonance imaging activity in multiple sclerosis. J. Neurol. 1999;246:454–458
  5. Roelcke U, Kappos L, Lechner-Scott J, et al.  Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566–1571
  6. Brownell B, Hughes JT. The distribution of plaques in the cerebrum in multiple sclerosis. J. Neurol., Neurosurg. Psychiatry. 1962;25:315–320
  7. Lumsden CE. The neuropathology of multiple sclerosis. In:  Vinken PJ,  Bruyn GW editor. Handbook of Clinical Neurology. vol. 9:Amsterdam: North-Holland; 1970;p. 217–309
  8. Kidd D, Barkhof F, McConnel R, Algra PR, Allen IV, Reverz T. Cortical lesions in multiple sclerosis. Brain. 1999;122:17–26
  9. Bakshi R, Dmochowski J, Shaikh ZA, Jacobs L. Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients. J. Neurol. Sci. 2001;185:19–26
  10. Cercignani M, Bozzali M, Iannucci G, Comi G, Filippi M. Magnetization transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis. J. Neurol., Neurosurg. Psychiatry. 2001;70:311–317
  11. Bozzali M, Cercignani M, Sormani MP, Martinelli V, Comi G, Filippi M. Grey matter involvement in different multiple sclerosis phenotypes: a diffusion tensor and magnetization transfer imaging study. [abstract] Proc. Int. Soc. Magn. Reson. Med. 2001;1:49
  12. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology. 1996;46:907–911
  13. Colombo B, Martinelli Boneschi F, Rossi P, et al.  MRI- and motor evoked potential findings in non-disabled multiple sclerosis patients with and without symptoms of fatigue. J. Neurol. 2000;247:506–509
  14. Bito Y, Hirata S, Yamamoto E. Optimal gradient factors for ADC measurement. [abstract] Proc. Int. Soc. Magn. Reson. Med. 1995;2:913
  15. Miller DH, Barkof F, Berry I, Kappos L, Scotti G, Thompson AJ. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. J. Neurol., Neurosurg. Psychiatry. 1991;54:683–688
  16. Talairach J, Tornaux P. A Co-Planar Stereotactic Atlas of the Human Brain. Stuttgart: Thieme; 1988;
  17. Lassmann H. Pathology of multiple sclerosis. In:  Compston A,  Ebers G,  Lassmann H,  McDonald I,  Mattews B,  Wekerle H editor. McAlpine's Multiple Sclerosis. London: Livingstone; 1998;p. 323–358
  18. Rovaris M, Filippi M, Minicucci L, et al.  Cortical/subcortical disease burden and cognitive impairment in multiple sclerosis. AJNR, Am. J. Neuroradiol. 2000;21:402–408
  19. Ge Y, Grossman RI, Udupa JK, Babb JS, Nyùl LG, McGowan JC. Tissue characterization in relapsing–remitting and secondary-progressive MS via magnetization transfer ratio. Proc. Int. Soc. Magn. Reson. Med. 2000;8:1189
  20. Presciutti O, Sarchielli P, Gobbi G, et al.  1H MRS study in occipital gray matter of multiple sclerosis. [abstract] Proc. Int. Soc. Magn. Reson. Med. 2000;8:627
  21. Filippi M. Multiple sclerosis: a white matter disease with associated grey matter damage. J. Neurol. Sci. 2001;185:3–4
  22. Miki Y, Grossman RI, Udupa JK, et al.  Isolated U-fiber involvement in MS: preliminary observations. Neurology. 1998;50:1301–1306

PII: S0022-510X(01)00682-7

Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 71-74 , 15 February 2002

Article Tools