Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 59-69 , 15 February 2002

Platelet adhesion and arteriolar dilation in the photothrombosis: observation with the rat closed cranial and spinal windows

  • Mami Ishikawa

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA. Tel.: +1-318-675-6011; fax: +1-318-675-6005
    • Clinical Research Unit, National Saitama Hospital, 2-1 Suwa, Wako-city, Saitama 351-0102, Japan
    • Department of Neurosurgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan
    • ,
  • Eiichi Sekizuka

      Affiliations

    • Clinical Research Unit, National Saitama Hospital, 2-1 Suwa, Wako-city, Saitama 351-0102, Japan
    • ,
  • Chikara Oshio

      Affiliations

    • Clinical Research Unit, National Saitama Hospital, 2-1 Suwa, Wako-city, Saitama 351-0102, Japan
    • ,
  • Shuzo Sato

      Affiliations

    • Department of Neurosurgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan
    • ,
  • Noriyuki Yamaguchi

      Affiliations

    • Department of Neurosurgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan
    • ,
  • Satoshi Terao

      Affiliations

    • Clinical Research Unit, National Saitama Hospital, 2-1 Suwa, Wako-city, Saitama 351-0102, Japan
    • ,
  • Kosuke Tsukada

      Affiliations

    • Faculty of Science and Technology, Institute of Biomedical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama-city, Kanagawa 223-8522, Japan
    • ,
  • Haruyuki Minamitani

      Affiliations

    • Faculty of Science and Technology, Institute of Biomedical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama-city, Kanagawa 223-8522, Japan
    • ,
  • Takeshi Kawase

      Affiliations

    • Department of Neurosurgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan

Received 26 July 2001 ,Revised 19 October 2001 ,Accepted 19 November 2001.

References 

  1. Rosenblum WI, El-Sabban F. Platelet aggregation in the cerebral microcirculation: effect of aspirin and other agents. Stroke. 1977;40:320–328
  2. Watson BD, Dietrich WD, Prado R, Nakayama H, Kanemitsu F, Futrell N, et al.  Concepts and techniques of experimental stroke induced by cerebrovascular photothrombosis. In:  Ohnishi ST,  Ohnishi T editor. Central nervous system trauma: laboratory techniques and recent advancement. Boca Raton, FL: CRC Press; 1995;p. 169–194
  3. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann. Neurol. 1985;17:497–504
  4. Dietrich WD, Watson BD, Busto R, Ginsberg MD, Bethea JR. Phatochemically induced cerebral infarction. Acta Neuropathol. (Berlin). 1987;72:315–325
  5. Nakayama H, Dietrich WD, Watson BD, Busto R, Dinsberg MD. Phtothrombotic occlusion of rat miccle cerebral artery recanalization. J. Cereb. Blood Flow Metab. 1988;8:357–366
  6. Umemura K, Wada K, Uematsu T, Nakashima M. Evaluation of the combination of a tissue-type plasminogen activator, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model. Stroke. 1993;24:1077–1082
  7. Watson BD, Dietrich WD, Prado R, Ginsberg MD. Argon laser-induced arterial photothrombosis: characterization and possible application to therapy of arteriovenous malformations. J. Neurosurg. 1987;66:748–754
  8. Yao H, Ibayashi S, Sugimori H, Fujii K, Fujishima M. Simplified model of krypton laser-induced thrombotic distal middle cerebral artery occlusion in spontaneously hypertensive rats. Stroke. 1996;27:333–336
  9. Futrell N. An improved photochemical model of embolic cerebral infarction in rats. Stroke. 1991;22:225–232
  10. Shimizu T, Sekizuka E, Nagai T, Kawamura T, Ishikawa M, Oshio C, et al.  Thrombus formation in microcirculation of diabetes mellitus. Microcirc. Annu. 1999;15:69–70
  11. Futrell N, Watson BD, Dietrich WD, Trado R, Millikan C, Ginsberg MD. A new model of embolic stroke produced by photochemical injury to the carotid artery in the rat. Ann. Neurol. 1988;23:251–257
  12. del Maschio A, Dejana E, Bazzoni G. Bidirectional modulation of platelet and polymorphonuclear leukocyte activities. Ann. Hematol. 1993;67:23–31
  13. Elstad MR, Mclntyre TM, Prescott SM, Zimmerman GA. The interaction of leukocytes with platelets in blood coagulation. Curr. Opin. Hematol. 1995;2:47–54
  14. Massberg S, Enders G, Leiderer R, Eisenmenger S, Vestweber D, Krombach F, et al.  Platelet–endothelial cell interactions during ischemia/reperfusion: the role of P-selectin. Blood. 1998;92:507–515
  15. Ruf A, Patscheke H. Platelet-induced neutrophil activation: platelet-expressed fibrinogen induces the oxidative burst in neutrophils by an interaction with CD11C/CD18. Br. J. Haematol. 1995;90:791–796
  16. Scalia R, Lefer AM. In vivo regulation of PECAM-1 activity during acute endothelial dysfunction in the rat mesenteric microvasculature. J. Leukocyte Biol. 1998;64:163–169
  17. Zwaginga JJ, Torres HI, Lammers J, Sixma JJ, Koenderman L, Kuijper PH. Minimal platelet deposition and activation in models of injured vessel wall ensure optimal neutrophil adjesion under flow conditions. Arterioscler., Thromb., Vasc. Biol. 1999;19:1549–1554
  18. Hossmann V, Hossmann KA, Takagi S. Effect of intravascular platelet aggregation on blood recirculation following prolonged ischemia of the cat brain. J. Neurol. 1980;222:159–170
  19. Konstantopulos K, Grotta JC, Sills C, Wu KK, Hellums JD. Shear-induced platelet aggregation in normal subjects and stroke patients. Thromb. Haemostasis. 1995;74:1329–1334
  20. Littleton-Kearney MT, Hurn PD, Kickler TS, Traystman RJ. Incomplete global cerebral ischemia alters platelet biology in neonatal and adult sheep. Am. J. Physiol. 1998;274:H1293–H1300
  21. Zeller JA, Tschoepe D, Kessler C. Circulating platelets show increased activation in patients with acute cerebral ischemia. Thromb. Haemostasis. 1999;81:373–377
  22. Ishikawa M, Sekizuka E, Shimizu K, Yamaguchi N, Kawase T. Measurement of RBC velocities in the rat pial arteries with an image-intensified high-speed video camera system. Microvasc. Res. 1998;56:166–172
  23. Morii S, Ngai ALC, Winn HR. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide: with detailed description of the closed cranial window technique in rats. J. Cereb. Blood Flow Metabol. 1986;6:34–41
  24. Ishikawa M, Sekizuka E, Sato S, Yamaguchi N, Shimizu K, Kobayashi K, et al.  In vivo rat closed spinal window for spinal microcirculation: observation of pial vessels, leukocyte adhesion and RBC velocity. Neurosurgery. 1999;44:156–162
  25. Dirnagl U, Niwa K, Sixt G, Villringer A. Cortical hypoperfusion after global forebrain ischemia in rats is not caused by microvascular leukocyte plugging. Stroke. 1994;25:1028–1038
  26. Ishikawa M, Sekizuka E, Sato S, Yamaguchi N, Inamasu J, Bertalanffy H, et al.  Effects of moderate hypothermia on leukocyte–endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion. Stroke. 1999;30:1679–1686
  27. Hartl R, Medary MB, Ruge M, Arfors KE, Ghajar J. Early white blood cell dynamics after traumatic brain injury: effects on the cerebral microcirculation. J. Cereb. Blood Flow Metab. 1997;17:1210–1220
  28. del Zoppo GJ, Garcia JH. Polymorphonuclear leukocyte adhesion in cerebrovascular ischemia: pathophysiologic implications of leukocyte adhesion. In:  Granger DN,  Schmid-Schonbein GW editor. Physiology and pathophysiology of leukocyte adhesion. New York: Oxford Univ. Press; 1995;p. 408–425
  29. Hallenbeck JM, Dutka AJ, Tanishima T, Kochanek PM, Kumaroo KK, Thompson CB, et al.  Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke. 1986;17:246–253
  30. Hartl R, Schurer L, Schmid-Schonbein GW, del Zoppo GJ. Experimental antileukocyte interventions in cerebral ischemia. J. Cereb. Blood Flow Metab. 1996;16:1108–1119
  31. Tomita M, Fukuuchi Y. Leukocyte, Macrophages and secondary brain damage following cerebral ischemia. Acta Neurochir., Suppl. 1996;66:32–39
  32. Yoshida Y, Dereski MO, Garcia JH, Hetzel FW, Chopp M. Neuronal injury after photoactivation of Photofrin II. Am. J. Pathol. 1992;141:989–997
  33. Said S, Rosenblum WI, Povlishock JT, Nelson GH. Correlations between morphological changes in platelet aggregates and underlying endothelial damage in cerebral microcirculation of mice. Stroke. 1993;24:1968–1976
  34. Fingar VH, Wieman TJ, Wiehle SA, Cerrito PB. The role of microvascular damage in photodynamic therapy: the effect of treatment on vessel constriction, permeability, and leukocyte adhesion. Cancer Res. 1992;52:4914–4921
  35. Fingar VH, Siegel KA, Wieman TJ, Doak KW. The effects of thromboxane infibitors on the microvascular and tumor response to photodynamic therapy. Photochem. Photobiol. 1993;58:393–399
  36. Gilissen MJ, van de Merbel-de Wit LEA, Star WM, Koster JF, Sluiter W. Effect of photodynamic therapy on the endothlium-dependent relaxation of isolated rat aortas. Cancer Res. 1993;53:2548–2552
  37. Selman SH, Kreimer-Birnbaum M, Klaunig JE, Goldblatt PJ, Keck RW, Britton SL. Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. Cancer Res. 1984;44:1924–1927
  38. Rosenblum WI, El-Sabban F, Ellis EF. Aspirin and indomethacin, nonsteroidal antiinflammatory agents alter the responses to microvascular injury in brain and mesentery. Microvasc. Res. 1980;20:374–378
  39. Weishaupt KR, Gomer CJ, Dougherty TJ. Indentification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor. Cancer Res. 1976;36:2326–2329
  40. Rosenblum WI, El-Sabban F. Dimethyl sulfoxide (DMSO) and glycerol, hydroxy radical scavengers, impair platelet aggregation within and eliminate the accoumpanying vasodilation of, injured mouse pial arterioles. Stroke. 1982;13:35–39
  41. Sato M, Natori T, Ohshima N. Effects of scavengers of active oxygens on the platelet thrombus formation in microvessels induced by photochemical reaction. Microcirc. Annu. 1987;3:135–136
  42. Leffler CW, Busija DW, Armstead WM, Shanklin DR, Mirro R, Thelin O. Activated oxygen and arachidonate effects on newborn cerebral arterioles. Am. J. Physiol. 1990;259:1230–1238
  43. Rosenblum WI. Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals. Am. J. Physiol. 1983;245:H139–H142
  44. Wei EP, Christman CW, Kontos HA, Povlishock JT. Effects of oxygen radicals on cerebral arterioles. Am. J. Physiol. 1985;248:H157–H162
  45. Burke TM, Wolin MS. Hydrogen peroxide elicites pulmonary arterial relaxation and guanylate cyclase activation. Am. J. Physiol. 1987;252:H721–H732
  46. Tan CM, Xenoyannis S, Feldman RD. Oxidant stress enhances adenylyl cyclase activation. Circ. Res. 1995;77:710–717

PII: S0022-510X(01)00673-6

Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 59-69 , 15 February 2002

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