Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 11-13, 15 February 2002

5′-Flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan

  • Hsiao-Sui Lo

      Affiliations

    • Department of Neurology, Taiwan Adventist Hospital, Taipei, Taiwan
    • ,
  • Edward L Hogan

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA
    • ,
  • Bing-Wen Soong

      Affiliations

    • Corresponding Author InformationCorresponding author. The Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan. Tel.: +886-2-2872-3307; fax: +886-2-2874-8631
    • Department of Neurology, National Yang-Ming University School of Medicine, Taiwan
    • The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

Received 4 December 2000; received in revised form 31 October 2001; accepted 31 October 2001.

Abstract 

Though the etiology of Parkinson's disease (PD) is unresolved and may be heterogeneous involving both environmental and genetic factors, there are indications that oxidative stress plays an important role in dopaminergic neuronal death. And, it has been reported that inhibition of nitric oxide synthase (NOS) can prevent the destruction of dopaminergic neurons in mammals. To determine if NOS gene polymorphism affects the 5′ flanking region that is immediately upstream of the transcription start site lying between the TATA element and CAATT boxes in PD, and differs significantly between patients with PD and normal controls, we studied genetic polymorphism in that region of the neuronal NOS gene in Chinese patients with PD living in Taiwan. The results indicate that the allele size distribution in that region was statistically significantly different between patients with PD and normal.

Keywords:  Parkinson's disease, NOS, Genetics, Chinese, Polymorphism

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PII: S0022-510X(01)00666-9

Journal of the Neurological Sciences
Volume 194, Issue 1 , Pages 11-13, 15 February 2002

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